In addition, the category, size, and surface charge of lipids also affect the behavior of lipid nanoparticles in vivo, so the optimization of lipid nanoparticle formulations for nucleic acid delivery has a long way to go. 4.1. Modification of mRNA In the last decade, new technological ...
The optimized LNPs encapsulating tumor-antigen encoding mRNA showed both prophylactic and therapeutic antitumor effects in mice. Keywords: mRNA; spleen; immune cell; vaccine; lipid nanoparticle 1. Introduction Delivering messenger RNA (mRNA) has gained substantial interest for purposes of vaccination due ...