Prediction of lipid nanoparticles for mRNA vaccines by the machine learning algorithm Lipid nanoparticleIonizable lipidmRNAVaccineFormulation predictionMachine learningLightGBMMolecular modelingLipid nanoparticle(LNP) is commonly used to deliver mRNA vaccines.Currently,LNP optimization primarily relies on screening ...
To unlock the full promise of messenger (mRNA) therapies, expanding the toolkit of lipid nanoparticles is paramount. However, a pivotal component of lipid nanoparticle development that remains a bottleneck is identifying new ionizable lipids. Here we describe an accelerated approach to discovering effec...
Predicting the potential toxicity of the metal oxide nanoparticles using machine learning algorithms Metal oxide nanoparticlesSine tree-seed algorithmPrediction modelOver the years, machine learning (ML) algorithms have proven their ability to make reliable ... GI Sayed,H Alshater,AE Hassanien - 《Soft...
Harnessing mRNA–lipid nanoparticles (LNPs) to treat patients with cancer has been an ongoing research area that started before these versatile nanoparticles were successfully used as COVID-19 vaccines. Currently, efforts are underway to harness this platform for oncology therapeutics, mainly focusing on...
Jones Day is representing METiS Pharmaceuticals, Inc. in connection with the establishment of global patent portfolios related to lipid nanoparticles (LNP) and uses thereof in various mRNA-based gene therapies. METiS focuses on leveraging artificial intelligence (AI), machine learning (ML), and molecu...
42 combine small-angle neutron scattering, molecular dynamics, and machine learning to study liquid lipid nanoparticles (LLN). They found out that the addition of the surfactant Brij O10 reduced the degree to which the lipids were self-organizing towards re-crystallization within the LLN. In ...
脂质体(Liposomes)、脂质纳米颗粒 (LNP,Lipid Nanoparticles) 和其他基于脂质的制剂已被临床证明可提高多种活性药物成分 (API,,active pharmaceutical ingredients) 的治疗指数。脂质是一类两亲性(amphipathic)生物分子,当掺入药物产品中时,它们表现出理想的安全性和药代动力学特征。最近,由于将 LNP 纳入基于信使 RNA ...
Antitumor effect of hyaluronic-acid-modified chitosan nanoparticles loaded with siRNA for targeted therapy for non-small cell lung cancer. Int J Nanomedicine. 2019;14:5287–301. Article CAS PubMed PubMed Central Google Scholar Li X, Wenes M, Romero P, Huang SC-C, Fendt S-M, Ho P-C. ...
Ionizable lipids are a key component of lipid nanoparticles, the leading nonviral messenger RNA delivery technology. Here, to advance the identification of ionizable lipids beyond current methods, which rely on experimental screening and/or rational design, we introduce lipid optimization using neural ...
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