Finally, I detail the different immune toxicities reported and propose ways to manipulate leukocytes' functions using LNPs.doi:10.1016/j.addr.2012.06.013Dan PeerElsevier B.V.Advanced Drug Delivery ReviewsPeer, D. Immunotoxicity Derived from Manipulating Leukocytes with Lipid-based Nanoparticles. Adv. ...
Lipid nanoparticles (LNPs) are becoming popular as a means of delivering therapeutics, including those based on nucleic acids and mRNA. The mRNA-based coro... H Mukai,K Ogawa,N Kato,... - 《Drug Metabolism & Pharmacokinetics》 被引量: 0发表: 2022年 Lipid Nanoparticle Technologies for Nucleic...
Lipid-based nanoparticles (LNPs), ranging from nanovesicles to non-lamellar assemblies, have gained significant attention in recent years, as versatile carriers for delivering drugs, vaccines, and nutrients. Small-angle scattering methods, employing X-rays (SAXS) or neutrons (SANS), represent unique ...
Jones Day is representing METiS Pharmaceuticals, Inc. in connection with the establishment of global patent portfolios related to lipid nanoparticles (LNP) and uses thereof in various mRNA-based gene therapies. METiS focuses on leveraging artificial intelligence (AI), machine learning (ML), and molecu...
In this study, lipid-based nanoparticles (LNPs) possessed an NK cell-like function that could deliver tumor-specific therapeutics and inhibit tumor growth. LNPs fused with an NK cell membrane protein system (NK-LNP) have three main features: (i) hydrophilic plasmid DNA can inhibit TNBC ...
6. Lipid Nanoparticles (LNPs) Over the past few decades, various delivery systems have been developed for nucleic acid-based vaccines, including viral vectors [210], non-viral vectors, as discussed above [211], and physical methods such as electroporation [212]. Viral vectors, such as adenoviru...
especially when used together with nanoparticles4. The reason of this phenomenon is that the functional site of RNA molecules is cytoplasm and they do not need to enter into the cell nucleus. The high efficacy of RNA vaccines has also been reported in cancer immunotherapy5,6. There are two ...
In that case, lipid nanoparticles (LNPs) are used to encapsulate the active pharmaceutical ingredients (API) which are viral protein-encoding mRNA. The vaccines are injected locally and intramuscularly, and the primary function of the LNPs is to protect the mRNA from degradation before cellular ...
Lipid-based nanoparticlesdrug deliverytumor cell surface targetingtumor vasculature targetingNanoparticle-mediated targeted drug delivery has become the modality of interest for cancer/tumor therapy as it reduces the undesirable delivery to normal cells and improves efficacy of the pharmaceuticals. Among all ...
Lipid nanoparticles (LNPs) have emerged as significant candidates for mRNA delivery in cancer immunotherapy, providing both protection to the mRNA and enhanced intracellular delivery efficiency. In this review, we offer a comprehensive summary of the recent advancements in LNP-based mRNA delivery systems...