But they brought their own difficulties. To get the negatively charged nucleic acids to associate with the LNPs, the lipids themselves needed to be positively charged – which made them toxic. Cullis’s solution was to develop an ionizable cationic lipid that would be positively charged in a lo...
In addition, LUNAR® lipids are pH-sensitive and biodegradable, causing minimal lipid accumulation in cells after multiple dosing [87] 6. LNP-nCoVsaRNA: Developed by Imperial College London using cationic liposome as the carrier, it has just entered phase 1 clinical trial [55]....
as an anti-toxin therapy (botulism model) and as an anti-tumor therapy (lymphoma model) [51]. They showed that a single injection of mRNA-LNP encoding either mAbs or camelid heavy-chain
Toxicity of mRNA LNPs can be multifaceted, including immune related toxicity events as well as cellular toxicities caused by the accumulation of lipids in the liver. Similar to other nanomedicines, LNPs have been reported to activate the complement system, which harbors the risk of eliciting a hype...