目的建立淋巴细胞性脉络丛脑膜炎病毒LCMV-CL13慢性感染小鼠模型,分析其作为B细胞受体高频突变研究模型的可能性.方法C57BL/6N小鼠经尾静脉途径接种2×10^(6)PFU剂量LCMV-CL13病毒,感染后第10,20,30,40,50,60,70天采集样品,通过qPCR检测组织病毒载量,流式检测分析外周血CD4^(+)T,CD8^(+)T,CD19^(+)B细胞...
Objective To establish an LCMV-CL13 chronic infection mouse model and analyze its use for B cell somatic hypermutation research. Methods C57BL/ 6N mice were inoculated with 2×106 plaque-forming units of LCMV- CL13 virus via tail vein injection. The tissue viral load was then detected by qua...
Virus dose LCMV cl-13 Persistent infection CD4+ T cells Wasting Cachexia TNFα IFNγ Introduction Individuals infected with viruses experience a loss in their quality of life. This loss may be short and transient, such as following an influenza virus infection, or may be life-long, as occurs...
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The immunosuppressive LCMV isolates WE54, LCMV Cl13, and Traub efficiently target antigen presenting cells (dendritic cells) in the spleen and perturb their ability to present antigen to T cells and B cells, resulting in a generalized immunosuppression of the host allowing viral persistence. These ...
The immunosuppressive LCMV isolates WE54, LCMV Cl13, and Traub efficiently target antigen presenting cells (dendritic cells) in the spleen and perturb their ability to present antigen to T cells and B cells, resulting in a generalized immunosuppression of the host allowing viral persistence. These ...
Integrating lentiviral vectors based on the human immunodeficiency virus type-1 (HIV-1) can transduce quiescent cells, which in lung account for almost 95%... MP Limberis,B Clheath - 《Molecular Therapy》 被引量: 60发表: 2010年 加载更多站...
CD45.1+P14-Nr4a1-GFP cells were adoptively transferred into CD45.2+mice 1 day prior infection with a high (2 × 106 ffu for chronic (C) infection) or low (200 ffu to induce an acute (A) infection) dose of LCMV clone 13. Three weeks post infection, P14 cells were sorted ...
This future America is very classist, and the tyrannical government is sure to keep the classes divided by heavily oppressing the working class. The working class is divided into twelve districts, which used to be thirteen districts until the thirteenth district was annihilated as a result of ...
GITR-/- mice have defective follicular helper CD4 T cell responses following LCMV cl 13 infection.doi:10.1371/JOURNAL.PPAT.1004517.G005Derek L. ClouthierA. ZhouM. WortzmanOlga LuftG. LevyT. WattsPLOS Pathogens