实验室,卫健委人类疾病比较医学重点实验室,北京㊀100021)㊀㊀ʌ摘要ɔ㊀目的㊀建立淋巴细胞性脉络丛脑膜炎病毒LCMV-CL13慢性感染小鼠模型,分析其作为B 细胞受体高频突变研究模型的可能性㊂方法㊀C57BL /6N 小鼠经尾静脉途径接种2ˑ106PFU 剂量LCMV-CL13病毒,感染 后第10㊁20㊁30㊁40㊁50...
Results LCMV-CL13-infected mice maintained a tissue viral load of 1×106 copies/ μL virus. The percentage of CD4+ T cells in the peripheral blood gradually increased in the infection plateau phase to ( 13. 15% ± 0. 72%), while the percentage of CD8+ T cells first decreased to ( ...