Results LCMV-CL13-infected mice maintained a tissue viral load of 1×106 copies/ μL virus. The percentage of CD4+ T cells in the peripheral blood gradually increased in the infection plateau phase to ( 13. 15% ± 0. 72%), while the percentage of CD8+ T cells first decreased to ( ...
DCs from Cl13 infected mice induce IL-10 expression in naïve LCMV specific CD4 T cells.Carmen Baca JonesChristophe FilippiSowbarnika SachithananthamTeresa RodríguezCalvoKatrin EhrhardtMatthias von Herrath
Seven tissues from chronically LCMV-infected mice were analyzed for infected (VL4+) cells 21 days post infection. Representative flow cytometry plots show PD-L1 and VL4 expression in hematopoietic (spleen) and peripheral tissues (lung) in the hematopoietic fractiona(gated on alive CD45+CD45.2+ce...
Selection of LCMV variants with distinguishable phenotypes occurs in different organs of infected mice persistently infected since birth with ARM tend to produce acute infection in adult mice, whereas isolates from the spleen of the same mice tend to persist ( Ahmed and Oldstone 1988)....
GITR-/- mice have impaired CD8 T cell responses and compromised control of chronic LCMV cl 13 infection.Derek, L. ClouthierAngela, C. ZhouMichael, E. WortzmanOlga, LuftGary, A. LevyTania, H. Watts
Of interest, the main immune cells infected with LCMV Clone 13 (CL13) in the BM were CD11b/c+myeloid DCs. We next characterized CD11b+DCs that differentiated during chronic LCMV infection. These DCs displayed a less immunogenic phenotype than DCs in naive or acutely infected mice, showing ...
GITR-/- mice have defective follicular helper CD4 T cell responses following LCMV cl 13 infection.doi:10.1371/JOURNAL.PPAT.1004517.G005Derek L. ClouthierA. ZhouM. WortzmanOlga LuftG. LevyT. WattsPLOS Pathogens