Contribution of LCMV transgenic models to understanding T lymphocyte development, activation, tolerance - Nguyen, Bachmann, et al. - 2002 () Citation Context ...ed in each of the thymocyte subpopulations (double-negative (DN), DP, and SP CD8) of mice injected with gp33–41C9M, supporting ...
P14 mice express a transgenic TCR recognizing the LCMV gp33 epitope.21 Negatively sorted CD8 þ T cells from Irf4 þ / þ or Irf4 À / À P14 transgenic TCR mice were then transferred into recombination-activating gene 1 (Rag1–/–) mice22 1 day before infection with a chronic...
Here, we characterize in vivo TCR signaling in virus-specific CD8 T cells in the setting of chronic LCMV infection. We use virus-specific TCR transgenic CD8 T cells expressing theNr4a1-GFP reporter as proxy for TCR signaling in adoptive transfer experiments. Despite abundant availability of antige...