Nygren H, Seppanen-Laakso T, Castillo S, Hyotylainen T, Oresic M: Liquid chromatography-mass spectrometry (LC-MS)-based lipidomics for studies of body fluids and tissues. Methods Mol Biol. 708:247-257, 2011Nygren, H., Seppa¨ nen-Laakso, T., Castillo, S., Hyo¨ tyla¨ inen, T....
LipidQuan:强大的高通量LC-MS平台,助力人血浆和血清中生物活性极性脂质的组学大规模筛选 沃特世 已认证账号 脂质在许多生物学过程中发挥着关键作用,其准确的测量对解开疾病和人类健康的生物学之谜至关重要。目前,脂质组分析有两种常用方法: 靶向分析:通常用于研究信号处理和假设驱动的通路分析; 全局分析(非靶向)...
由于它们的多功能性和效率,液相色谱-质谱(LC-MS)仪器在许多现代分析实验室中已成为人们所最为希望的分析方法。 什么是LC-MS? LC-MS是一种分析技术,涉及目标化合物(或分析物)的物理分离,然后进行基于质量的检测。尽管相对较新,但它的灵敏度,选择性和准确性使其成为检测微克甚至纳克量的各种分析物(从药物代谢物...
1. Cajka, T.; Fiehn, O. Toward Merging Untargeted and Targeted Methods in Mass Spectrometry-Based Metabolomics and Lipidomics. Anal. Chem., 2016, 88, 524–545. 2. Xia, J., Psychogios, N., Young, N. and Wishar...
液相色谱与串联质谱联用(LC-MS / MS) 通过耦合两个串联运行的质量分析仪,可以进一步提高样品识别和准确定量的水平。三重四极杆质谱仪(QQQ或TQMS)和四极杆飞行时间(QTOF)是最常用的串联质谱仪。这些配置为样品分析提供了几种可能性。 TQMS由两个四极杆质量分析仪(Q 1和Q ...
To avoid fraudulent practices, LC-MS-based lipidomics has been a feasible approach for authentication and discrimination of meat from different source (Mi et al., 2018). In order to identify the distinguishing lipid markers in the meat samples of three different species, three pairwise ...
Multiplelipidomicsmethods for targeted and non-targeted approaches — shotgun, LC, MS and MS/MS — necessitate the use of multiple software programs to automate data analysis. There is no informatics suite that supports automated data analysis of all the above mentioned methods.SimLipid softwarehas...
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Multi-Omics Data Analysis Mass Spectral Libraries Cloud-Based Technologies for Mass Spectrometry LC-MS Data Processing Software Acquiring high-quality data doesn’t need to be a challenge Acquire the highest quality data possible to unlock th...
Lipid peroxidation Oxidative stress LC-MS/MS Targeted analysis 1. Introduction Oxidative stress (OS) originates from exposure to reactive oxygen species (ROS): superoxide anion, hydroxyl radical and hydrogen peroxide are the main species that can give OS damage to biological targets such as proteins...