乳酸化修饰(Lactylation)是RNA m6A去甲基化酶ALKBH5存在的一种新型酰化修饰形式,具有激活抗DNA病毒天然免疫应答、调控基因表达和蛋白质功能等多种作用,并与肿瘤的发生、发展密切相关。 Lactylation:乳酸化修饰的奥秘与前景 'Lactylation'的定义与基本概念 乳酸化修饰(Lactylation),作为一种...
1Citations 10Altmetric Metrics Cells sense and adapt to oxygen availability. A new study published inCell Researchreports that hypoxia-induced mitochondrial protein lactylation halts oxidative phosphorylation, underscoring the swift cellular response to low oxygen. ...
influencing the fate and function of T cells [22]. Moreover, LKB1 suppresses histone H4 lactylation, altering the activity of the transcription factor Sp1, which subsequently inhibits telomerase activity, leading to tumor cell senescence [23]. Lactylation has also been linked to ...
In Nature, Zhao and colleagues show that lactate drives the lactylation of histone lysine residues and directly modulates gene transcription. In human HeLa cells and mouse bone marrow–derived macrophages (BMDMs), histone lysine lactylation (Kla) is driven by extracellular lactate or glucose-...
Discoidin, CUB, and LCCL domain-containing type I (DCBLD1) is identified as an oncogene involved in multiple regulation of tumor progression, but specific mechanisms remain unclear in cervical cancer. Lactate-mediated lactylation modulates protein functi
ArticleLactylation-driven METTL3-mediated RNA m 6 Amodif i cation promotes immunosuppression oftumor-inf i ltrating myeloid cellsGraphical abstractHighlightsd H3K18 lactylation increases Mettl3 expression in tumor-inf i ltrating myeloid cellsd METTL3-mediated m 6 A modif i cation on Jak1 mRNA...
Besides, the article highlights the latest research progress concerning the regulatory functions of protein lactylation in pathological processes and underscores its scientific significance for future investigations. 展开 关键词: Lactic acid Lactylation Protein posttranslational modifications Metabolism Disease ...
This study investigates whether lysine lactylation (Kla), a lactate-derived post-translational modification in macrophages, occurs in brain cells and if it does, whether Kla is induced by the stimuli that accompany changes in lactate levels. Here, we show that Kla in brain cells is regulated ...
The lactylation at K147 in turn can reduce ALDOA enzymatic activity, perhaps forming a negative feedback loop by which cell can decrease the excessive lactate levels [24]. Besides, another glycolytic enzyme, α-enolase was also identified to undergo lactylation at K343, which might impact ...
In this study, we found that elevated lactic acid levels promote H3K18 lactylation in senescent microglia and the hippocampus of naturally aged mice and AD mice. Treatment of senescent microglia with Lactate dehydrogenase inhibitors leads to a dramatic decrease in lactic acid levels, which cause a...