POST-translational modificationPROTEIN conformationMETABOLIC disordersMOLECULAR biologyCARDIOVASCULAR diseasesCardiovascular disease (CVD) is recognized as the primary cause of mortality and morbidity on a global scale, and developing a clear treatment is an important tool for improving it. Cardiometab...
Notably, the posttranslational modification of proteins by lactylation has emerged as a crucial mechanism by which lactate regulates cellular processes. This article provides an overview of the discovery of lactate acidification, outlines the potential "writers" and "erasers" responsible for protein la...
Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells 下载积分: 500 内容提示: ArticleLactylation-driven METTL3-mediated RNA m 6 Amodif i cation promotes immunosuppression oftumor-inf i ltrating myeloid cellsGraphical abstractHighlightsd H3...
Herein, we elucidated the mechanism by which lactylation modification stabilizes the DCBLD1 protein. Furthermore, we investigated DCBLD1 overexpression activating pentose phosphate pathway (PPP) to promote the progression of cervical cancer. Methods DCBLD1 expression was examined in human cervical ...
Bladder cancer (BC) is one of the most common malignancies of the genitourinary system. Phosphofructokinase 1 (PFK-1) is one of member of PFK, which plays an important role in reprogramming cancer metabolism, such as lactylation modification. Zinc finger
It has been demonstrated that histone lactylation modification contributes to the transcriptional regulation of downstream genes [30]. To identify the H4K12la-target gene after SCI, we used genome-wide CUT&Tag analysis to identify candidate genes regulated by H4K12la. CUT&Tag analysis utilizing an...
lactylation modification.DKupffer cells isolated from C57BL/6 mice were treated with lactate (5 mmol/l) at day 3. Afterward, the protein expression levels of lac-RIG-I, MAVS, TRAF6, p-NF-kB P50, p-NF-kB P65, and p-IRF3 were detected via western blot.EThe protein expression ...
to strengthen its effect on ac4C acetylation, mRNA stabilization and inflammasome activation [14]. Given that tRNAs are the most densely modified by NAT10 [5,19,20], we speculated that the tRNAs of KSHV-encoded lytic genes might also employ NAT10-mediated ac4C modification to increase translatio...
found that YiaC can act as the writer to catalyze the addition of Kla, whereas CobB can act as eraser to remove this modification in E. coli [29]. Together, the discovery of widespread Kla sites and their regulatory enzymes greatly promoted the process to explore functional Kla events which...
The METTL3-mediated m6A modification is enriched in ACSL4, and its mRNA stability is regulated through a YTHDC1-dependent pathway. Furthermore, short-term lactate stimulation upregulates ACSL4, which promotes mitochondria-associated ferroptosis. Inhibition of METTL3 through knockdown or targeted ...