These results reveal a histone lactylation-driven mechanism inducing ferroptosis through METTL3-mediated m6A modification. Targeting METTL3 represents a promising therapeutic strategy for patients with sepsis-associated ALI.关键词 FerroptosisHistone lactylationN6- methyladenosineSepsis-associated acute lung ...
Abstract As an emerging metabolite-mediated post-translational modification, lysine lactylation (Kla) is discovered on histones that regulates gene transcription from chromatin. However, whether lactylation could occur outside the nucleus across broad proteins and its regulatory enzymes remains unclear. ...
翻译标题与摘要 更多引用 导出 Endnote Noteexpress 摘要 The activation and functional differentiation of CD8+ T cells are linked to metabolic pathways that result in the production of lactate. Lactylation is a lactate-derived histone post-translational modification; however, the relevance of histone...