Recently, lactic acid has been found to induce a posttranslational modification, lactylation, that may offer insight into lactic acid's non-metabolic functions. Notably, the posttranslational modification of proteins by lactylation has emerged as a crucial mechanism by which lactate regulates ...
gondii. This study offers the first dataset of the global lactylation proteome and provides a basis for further dissecting the functional biology of T. gondii.Previous article in issue Next article in issue Keywords Toxoplasma gondii Lactylation Protein post-translational modification Metabolism ChIP-...
Lysine lactylation K: Lysine TCA: Tricarboxylic acid TME: Tumor microenvironment PTM: Post-translational modification MS/MS: Tandem mass spectrometric LDHA: Lactate dehydrogenase A Vps34: Vacuolar protein sorting 34 E. coli : Escherichia coli HMGB1: High mobility group box-1 YY1: ...
This study investigates whether lysine lactylation (Kla), a lactate-derived post-translational modification in macrophages, occurs in brain cells and if it does, whether Kla is induced by the stimuli that accompany changes in lactate levels. Here, we show that Kla in brain cells is regulated ...
Recently, lactic acid has been found to induce a posttranslational modification, lactylation, that may offer insight into lactic acid's non-metabolic functions. Notably, the posttranslational modification of proteins by lactylation has emerged as a crucial mechanism by which lactate regulates ...
A diagnostic fragment ion in tandem mass spectrometry enables confident protein lactylation assignment and the discovery of broad lysine modification beyond histones. This is a preview of subscription content, access via your institution Access options Access Nature and 54 other Nature Portfolio ...
TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation. Proc Natl Acad Sci. 2020;117:30628–38. Article CAS PubMed PubMed Central Google Scholar Ward PS, Thompson CB. Metabolic reprogramming: a cancer hallmark even warburg did not ...
High-altitude cerebral edema (HACE) is considered an end-stage acute mountain sickness (AMS) that typically occurs in people after rapid ascent to 2500 m or more. While hypoxia is a fundamental feature of the pathophysiological mechanism of HACE, em
(Khib), β-hydroxybutyrylation (Kbhb), succinylation (Ksucc), and lactylation (Kla) have been identified [2,3] (Fig.1). These modifications influence protein structure and modulate their stability, localization, and activity [4]. Based on the chemical properties of lysine modification, ...
Being bullied leaves a biochemical footprint in the brain. Protein lactylation is a very recently discovered post-translational modification of protein that involves the addition of a lactyl group to lysine residues. Researchers at the Institute for Comprehensive Medical Science at Fujita Health Univers...