This study investigates whether lysine lactylation (Kla), a lactate-derived post-translational modification in macrophages, occurs in brain cells and if it does, whether Kla is induced by the stimuli that accompany changes in lactate levels. Here, we show that Kla in brain cells is regulated ...
Protein lactylation induced by neural excitation. Cell Rep. 2021;37(2): 109820. Article CAS PubMed Google Scholar Brooks GA. Cell-cell and intracellular lactate shuttles. J Physiol. 2009;587(Pt 23):5591–600. Article CAS PubMed PubMed Central Google Scholar Halestrap AP, Price NT. ...
lactylationlactatebrainneuronal activitypost-translational modificationhistone H1stressprefrontal cortexLactate has diverse roles in the brain at the molecular and behavioral levels under both physiological and pathophysiological conditions. It is unknown whetherHagihara, Hideo...
Oxidative phosphorylation (OXPHOS) consumes oxygen to produce ATP. However, the mechanism that balances OXPHOS activity and intracellular oxygen availability remains elusive. Here, we report that mitochondrial protein lactylation is induced by intracellu
High-altitude cerebral edema (HACE) is considered an end-stage acute mountain sickness (AMS) that typically occurs in people after rapid ascent to 2500 m or more. While hypoxia is a fundamental feature of the pathophysiological mechanism of HACE, em
Notably, the posttranslational modification of proteins by lactylation has emerged as a crucial mechanism by which lactate regulates cellular processes. This article provides an overview of the discovery of lactate acidification, outlines the potential "writers" and "erasers" responsible for protein la...
2024年1月2日，复旦大学赵世民/徐薇合作团队在Cell Research杂志发表题为“Hypoxia Induces Mitochondria Protein Lactylation to Limit Oxidative Phosphorylation”的封面论文，发现线粒体蛋白质乳酰化修饰被肌肉细胞低氧激活，表征运动程度，并通过抑制线粒体氧化磷酸化预防过度运动损伤。他们发现，线粒体丙氨酰tRNA合成酶...
Lysine lactylation (Kla) is a type of post-translational modifications (PTMs) that has been recently associated with chromatin remodeling; however, Kla of histone and non-histone proteins has not yet been studied in T. gondii. To examine the prevalence and function of lactylation in T. ...
A diagnostic fragment ion in tandem mass spectrometry enables confident protein lactylation assignment and the discovery of broad lysine modification beyond histones. This is a preview of subscription content, access via your institution Access options Access Nature and 54 other Nature Portfolio ...
This paper shows that protein lactylation in brain cells is regulated by neural activation and social defeat stress, paralleled with changes in lactate levels. The stress specifically enhances lysine lactylation of histone H1 proteins in neurons in the prefrontal cortex (PFC). Credit: Hagihara H,...