Lactylation and HCC progressiondoi:10.1038/s41575-023-00746-7Eleni KotsilitiNature Reviews Gastroenterology & HepatologyNature Publishing Group UKNature Reviews Gastroenterology & Hepatology
Lactylation and HCC progression Eleni Kotsiliti Nature Reviews Gastroenterology & HepatologyResearch Highlight07 Feb 2023 Nature Metabolism (Nat Metab)ISSN2522-5812(online) Sign up for theNature Briefing: Cancernewsletter — what matters in cancer research, free to your inbox weekly. ...
including esophageal cancer (EC), gastric cancer (GC), colorectal cancer (CRC), hepatocellular carcinoma (HCC), and pancreatic cancer (PC), among others. The occurrence and progression of these malignant tumors involve a complex and multifactorial process...
Non-histone lactylation modifications have been increasingly recognized for their role in tumor progression. For example, the lactylation of adenylate kinase 2 has been shown to enhance the proliferation and metastasis of hepatocellular carcinoma (HCC) [16]. Lactylation is also involved in the ...
Gu et al. demonstrated that lactate can facilitate the Kla of MOESIN at K72 residue to regulate the development and immunosuppressive function of Treg cells, and HCC patients who responded to anti-PD-1 treatment have lower MOESIN Kla levels in Treg cells than nonresponding patients [33]. ...
breast cancer [25], [26], [27], [28], [29], we explored the gene regulations mediated by histone lactylation by performing our experiments using cell lines that represent two of the commonly detected and widely studied types of breast cancer- luminal A (MCF7) and basal subtype (HCC...
Interferon regulatory factor 1(IRF-1) activates anti-tumor immunity via CXCL10/CXCR3 axis in hepatocellular carcinoma (HCC). Cancer Lett. 2021;506:95–106. Article CAS PubMed PubMed Central Google Scholar Hagihara H, Catts V, Katayama Y, Shoji H, Takagi T, Huang F, et al. Decreased ...
Liver cancer stem cells (LCSCs) are thought to participate directly in HCC progression and recurrence. These cells promote primary cancer cell growth and secondary tumor metastasis after transplantation, leading to disease recurrence, thus, serving as an important diagnostic marker of HCC [2]. ...
Lastly, core DEGs also exhibited upregulation in HCC. Discussion: Lactylation extensively participates in the pathological progression and immune infiltration of fibrosis. Lactylation and related immune infiltration could be a worthy focus for the investigation of HCC developed from ...
Breast cancer (BC) stands as a predominant global malignancy, significantly contributing to female mortality. Recently uncovered, histone lysine lactylation (kla) has assumed a crucial role in cancer progression. However, the correlation with lncRNAs rem