肝脏和血液中KLRG1+ NK细胞增加与慢性乙型肝炎患者低纤维化阶段有关。此外,在CD44配体骨桥蛋白刺激后,KLRG1 + NK细胞CD44表达增加,脱颗粒和IFNγ产生增加,提示肝星状细胞来源的骨桥蛋白可能导致KLRG1 + NK细胞活化。 KLRG1+ NK细胞可能在HBV感染的...
, CD44, ICOS, and KLRG1) and various chemokine receptors responsible for tissue location but display low expression of CD62L and CCR7 [6]. Conditional deletion of TCRα after Treg maturation blocks eTreg generation and causes a severe autoimmune phenotype resembling Scurfy mice, indicating that ...
Finally, the expression of CD44, degranulation and IFN-纬 production were all increased in KLRG1+ NK cells following stimulation with osteopontin, the CD44 ligand, suggesting that HSC-derived osteopontin may cause KLRG1+ NK cell activation. Conclusions: KLRG1+ NK cells likely play an antifibrotic ...
肝脏和血液中KLRG1+ NK细胞增加与慢性乙型肝炎患者低纤维化阶段有关。此外,在CD44配体骨桥蛋白刺激后,KLRG1 + NK细胞CD44表达增加,脱颗粒和IFNγ产生增加,提示肝星状细胞来源的骨桥蛋白可能导致KLRG1 + NK细胞活化。 KLRG1+ NK细胞可能在HBV感染的自然过程中发挥抗纤维化作用,可能为慢性乙型肝炎肝纤维化治疗提供一种...
Finally, KLRG1+ NK cells had higher expression of CD44 and increased degranulation and IFN-纬 production following stimulation with osteopontin, the CD44 ligand, suggesting that HSCs derived osteopontin may cause KLRG1+ NK cells activation. KLRG1+ NK cells likely play an anti-fibrotic role during ...