KLRG1 and KLRG1 CD8 T cells were sorted for transcriptome analysis. The impact of the KLRG1-E-cadherin pathway on the suppression of HBV replication mediated by virus-specific T cells was validated in vitro. As expected, HBV-specific CD8 T cells expressed higher le...
Killer cell lectin-like receptor subfamily G, member1-KLRG1属于杀伤细胞凝集素样受体,是NK 优先表达的一类跨膜蛋白,胞内含有ITIM基序,是淋巴细胞共抑制或免疫检查点受体,主要表达于晚期分化效应和效应记忆CD8+ T细胞和NK细胞。 KLRG1 包涵体肌炎(IBM)是一种缓慢进展的骨骼肌疾病,具有独特的临床和病理特征(包括手指...
Vicente R et al. Nonclassical CD4+CD49b+ Regulatory T Cells as a Better Alternative to Conventional CD4+CD25+ T Cells To Dampen Arthritis Severity. J Immunol. 2016 Jan 1;196(1):298-309. Tauro S et al. Diversification and senescence of Foxp3+ regulatory T cells during experimental autoimmu...
KLRG1(killer cell lectin-like receptor G1),杀伤性细胞凝集素样受体G1,就是其中一种抑制分子。目前研究发现,KLRG1在NK细胞和部分CD8+T细胞,以及一些肥大细胞和嗜碱性粒细胞中有较高水平表达。尽管KLRG1已经作为小鼠 CD8+T细胞衰老和终端效应的分化的关键指标,但是KLRG1在人类细胞中的功能仍不清晰。与小鼠相似,有研...
KLRG1作为免疫检查点受体,相比PD-1与CTLA-4,在CD8+T细胞和NK细胞上表达更高,而且与CD8+T细胞功能高度相关。 Abcuro是最早进行KLRG1靶点开发的Biotech公司(2021年获得Mass General Brigham Ventures和 Sanofi Ventures 4200万美金投资),其创始人Steven A. Greenberg曾经发表过多篇 ...
The killer cell lectin-like receptor G1 (KLRG1) is a unique inhibitory receptor expressed on a phenotypically mature subset of resting NK cells as well as effector memory CD8T cells. KLRG1 is a C-type lectin inhibitory receptor that contains an immunoreceptor tyrosine-based inhibitory motif (...
在小鼠肺癌模型中,特异性消除klrg1 + cd103 + treg细胞能够增加cd8+t细胞的浸润、减轻肿瘤负担。 使用jq1(bet抑制剂)/抗pd-1治疗,能够增加非小细胞癌小鼠存活率,与细胞中 klrg1 + treg细胞水平有关。 cancer immunol res. 2018 oct;6(10):1234-1245. 包括metha、mca...
Beyersdorf NB, Ding X, Karp K, Hanke T. Expression of inhibitory "killer cell lectin-like receptor G1" identifies unique subpopulations of effector and memory CD8T cells.Eur J Immunol. 2001; 31(12):3443-3452. Henson SM, Akbar AN. KLRG1--more than a marker for T cell senescence.Age ...
Functional CD8 T cell effector and memory responses are generated and maintained during murine γ-herpesvirus 68 (γHV68) persistent infection despite continuous presentation of viral lytic Ags. However, the identity of the CD8 T cell subpopulations that mediate effective recall responses and that can...
The inhibitory receptor KLRG1 and the integrin αE (CD103) are expressed by CD8(+) T cells and both are specific for E-cadherin. However, KLRG1 ligation by E-cadherin inhibits effector T-cell function, whereas binding of CD103 to E-cadherin enhances cell-cell interaction and promotes target...