KLRG1:T 细胞大颗粒淋巴细胞白血病(T-LGLL)诊疗新突破的关键靶点 《Cell Reports Medicine》:KLRG1 re-defines a leukemic clone of CD8 effector T cells sensitive to PI3K inhibitor in T cell large granular lymphocytic leukemia 编辑推荐: 本文聚焦 T 细胞大颗粒淋巴细胞白血病(T-LGLL),研究发现 KLRG1 可界定...
Killer cell lectin-like receptor subfamily G, member1-KLRG1属于杀伤细胞凝集素样受体,是NK 优先表达的一类跨膜蛋白,胞内含有ITIM基序,是淋巴细胞共抑制或免疫检查点受体,主要表达于晚期分化效应和效应记忆CD8+ T细胞和NK细胞。 KLRG1 包涵体肌炎(IBM)是一种缓慢进展的骨骼肌疾病,具有独特的临床和病理特征(包括手指...
T cellsCD8 antigenT-cell exhaustionKILLER cell receptorsKiller cell lectin-like receptor G1 (KLRG1) has traditionally been regarded as an inhibitory receptor of T cell exhaustion in chronic infection and inflammation. However, its exact role in hepatitis B virus (HBV) infection re...
基于的前体是KLRG1在具有自身反应性的效应记忆T细胞(effector memory T, TEM)高表达,ABC008通过ADCC效应清除表达KLRG1+ TEM,治疗自身免疫性疾病,以及表达KLRG1的T细胞大颗粒淋巴细胞白血病。 靶向KLRG1的新型肿瘤治疗策略 肿瘤诱导KLRG1表达升高,使Treg细胞抑制功能增强,NK、Teff细胞毒性减弱,因此,在肿瘤治疗中同时靶向Teff...
KLRG1作为免疫检查点受体,相比PD-1与CTLA-4,在CD8+T细胞和NK细胞上表达更高,而且与CD8+T细胞功能高度相关。 Abcuro是最早进行KLRG1靶点开发的Biotech公司(2021年获得Mass General Brigham Ventures和 Sanofi Ventures 4200万美金投资),其创始人Steven A. Greenberg曾经发表过多篇 ...
Beyersdorf NB, Ding X, Karp K, Hanke T. Expression of inhibitory "killer cell lectin-like receptor G1" identifies unique subpopulations of effector and memory CD8T cells.Eur J Immunol. 2001; 31(12):3443-3452. Henson SM, Akbar AN. KLRG1--more than a marker for T cell senescence.Age ...
在小鼠肺癌模型中,特异性消除klrg1 + cd103 + treg细胞能够增加cd8+t细胞的浸润、减轻肿瘤负担。 使用jq1(bet抑制剂)/抗pd-1治疗,能够增加非小细胞癌小鼠存活率,与细胞中 klrg1 + treg细胞水平有关。 cancer immunol res. 2018 oct;6(10):1234-1245. 包括metha、mca...
Dolfi D.V., et al. Increased T-bet is associated with senescence of influenza virus-specific CD8 T cells in aged humans. Journal ofLeukocyte Biology 93(6):825–836 (2013). Voehringer D., et al. Lack of proliferative capacity of human effector and memory T cells expressing killer cell ...
cells, whereas NAPC increased the infiltration of CD20+B cells, CD4+T cells, CD4+CD127+T cells, CD8+T cells, CD8+CD127+and CD8+KLRG1+T cells. Synergistic increase in B and T cells promotes favorable therapeutic response after NAPC. Spatial distribution analysis discovered that CD8+T cells...
The killer cell lectin-like receptor G1 (KLRG1) is a unique inhibitory receptor expressed on a phenotypically mature subset of resting NK cells as well as effector memory CD8T cells. KLRG1 is a C-type lectin inhibitory receptor that contains an immunoreceptor tyrosine-based inhibitory motif (...