2025年2月14日,来自耶鲁大学的Nikhil S. Joshi团队在Science发表了标题为“KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection.”的研究成果,发现单细胞CRISPR筛选(PerturbSEQ)揭示了转录因子KLF2在维持CD8+ T细胞效应谱系稳定性和抑制T细胞耗竭中的关键作用,为免疫治疗提...
沉默KLF2促使CD8 T细胞沿着不同的分化路径发展,引导它们远离杀伤性T细胞,进入一种称为衰竭的功能失调状态,这种状态会降低这些细胞对抗感染和控制肿瘤进展的有效性。 KLF2可阻止急性淋巴细胞性脉络丛脑膜炎病毒(LCMV)感染中CD8 T细胞的异常分化 Joshi 将这一发现比作一辆汽车从高速公路切换到乡村公路。在感染或肿瘤中,我...
沉默KLF2促使CD8 T细胞沿着不同的分化路径发展,引导它们远离杀伤性T细胞,进入一种称为衰竭的功能失调状态,这种状态会降低这些细胞对抗感染和控制肿瘤进展的有效性。 Joshi 将这一发现比作一辆汽车从高速公路切换到乡村公路。在感染或肿瘤中,我们希望CD8 T细胞沿着高效、直接的高速公路成为有效的杀伤性T细胞。但在癌症中,C...
Eric Fagerberg et al,KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection, Science (2025). DOI: 10.1126/science.adn2337. 版权声明 本网站所有注明“来源:生物谷”或“来源:bioon”的文字、图片和音视频资料,版权均属于生物谷网站所有。非经授权,任何媒体、网站或...
KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection KLF2在急性LCMV感染期间维持谱系保真度并抑制CD8 T细胞耗竭 相关领域 KLF2生物CD8型效应器细胞生物学细胞毒性T细胞清脆的T细胞祖细胞免疫系统转录因子细胞分化表观遗传学免疫学遗传学干细胞基因体外 ...
T cell exhaustion, a state of dysfunction occurring during chronic infections and cancer, is marked by a progressive loss of effector functions and increased expression of inhibitory receptors. In chronic infection, CD8 T cells differentiate into TCF1+ progenitor (TPRO), CX3CR1+ effector (TEFF)...
ʌ摘要ɔ 肺K r üp p e l 样转录因子(K L F 2/L K L F )是锌指K r üp p e l 样转录因子家族成员之一,由于最初发现K L F 2主要在肺内表达因此也称为L K L F ㊂研究表明K L F 2在肺与血管的发育,T 细胞静止㊁活化和迁移中起重要作用㊂近年的研究表明,K L F 2对许多疾病的发生...
Carbonic anhydrase IX promotes myeloid-derived suppressor cell mobilization and establishment of a metastatic niche by stimulating G-CSF production. Cancer Res. 2015;75. Zhang W, Zhang C, Li W, Deng J, Herrmann A, Priceman SJ, et al. CD8+ T-cell immunosurveillance constrains lymphoid pre...
参考资料: Eric Fagerberg et al, KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection, Science (2025). DOI: 10.1126/science.adn2337.
FOXP1 and KLF2 Modulate the Transition from Stem-like to Effector in CAR T Celldoi:10.4049/jimmunol.212.supp.0783.4826T cells are a pivotal component of the immune system in combating infections and cancer. In cancer, the presence of self-renewing, stem-like CD8+ T cell subpopulation is ...