KLF2, a negative regulator of T cell proliferation, has been implicated in T cell quiescence. KLF2 or SHIP expression in Jurkat cells caused 45% or 60% reduction of proliferation, respectively. SHIP can up-regulate KLF2 expression, implicating KLF2 in the SHIP-mediated growth inhibition of a ...
proliferation, growth, survival, and external stress responses. Alterations in their functions have been linked to many human diseases, including metabolic diseases and cancer (1-3). KLF2 is a key regulator in the differentiation and function of immune cells and vascular endothelial cel...
2C). In contrast, reduced expression of KLF2 significantly retarded cell proliferation (Fig. 2D, E and F). Flow cytometry analysis revealed that KLF2-depleted MM1.S/BTZ and NCI-H929/BTZ cells showed a dramatic increase in the apoptotic rate and the G0/G1 phase as compared with si-NC ...
Cell proliferation and NFκB activity assays were carried out 48 h post-transfection. Lentiviral overexpression of KLF2 c.862C>T p.H288Y mutant Lentiviral constructs for KLF2 overexpression were generated as described in ref. 29. Human KLF2 ORF was generated by PCR from SC127849 cDNA (...
Kang T, Liu L, Tan F, Zhang D, Yu L, Jiang H, Qian W, Hua J, Zheng Z. Inhibition of YTHDF1 prevents hypoxia-induced pulmonary artery smooth muscle cell proliferation by regulating Foxm1 translation in an m6A-dependent manner. Exp Cell Res. 2023;424(2): 113505. Article CAS PubMed...
Hwang HW, Mendell JT (2007) MicroRNAs in cell proliferation, cell death, and tumorigenesis. Br J Cancer 96:R40–R44 PubMed Google Scholar Kawanami D, Mahabeleshwar GH, Lin Z et al (2009) Kruppel-like factor 2 inhibits hypoxia-inducible factor 1alpha expression and function in the endothel...
KLF2, a nuclear DNA-binding transcription factor of the Kru¨ppel zinc-finger family, is involved in various biological processes including blood vessel and lung formation, as well as T-cell homeostasis18. KLF2 is also expressed in B cells19,20, and absence of KLF2 in B-cell compartment ...
Carbonic anhydrase IX promotes myeloid-derived suppressor cell mobilization and establishment of a metastatic niche by stimulating G-CSF production. Cancer Res. 2015;75. Zhang W, Zhang C, Li W, Deng J, Herrmann A, Priceman SJ, et al. CD8+ T-cell immunosurveillance constrains lymphoid pre...
Knockdown of DLK4 inhibits non-small cell lung cancer tumor growth by downregulating CKS2 The co-expression pattern of VEGFR-2 with indicators related to proliferation, apoptosis, and differentiation of anagen hair follicles Inflammation-related signaling pathways in tendinopathy CD4+ T cell count...
T cell receptor (TCR) transgene KRN and the MHC class II molecule A(g7) generates K/BxN mice; KLF2: kruppel-like factor 2 (lung); 3MA: 3-methyladenine; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MDC: monodansylcadaverine; NFATc1: nuclear factor of activated T ...