clusters tended to decrease (Fig.1d, e). This trend in cell ratios reflects the possibility that CD127-expressing T cells and KLRG1-expressing CD8+T cells are the main immune cell types mediating anti-tumor immunity after the addition of PD-1 blockade to neoadjuvant chemotherapy. We compared ...
NAC resulted in an increase only of CD20(+) B cells, whereas NAPC increased the infiltration of CD20(+) B cells, CD4(+) T cells, CD4(+)CD127(+) T cells, CD8(+) T cells, CD8(+)CD127(+) and CD8(+)KLRG1(+) T cells. Synergistic increase in B and T cells promotes favorable ...
Interestingly, high Blimp-1 expression is associated with increased PD-1, CTLA-4, and CD160 expression in chronic HIV infection [60]. Lack of Blimp-1 causes defective cytolytic functions in virus-specific CD8+ T cells and low expression of KLRG1 [74]. Blimp-1 and T-bet appear to have ...
KLRG1 is not expressed on mast cells in mice or humans [2,13,30]. Recent advances indicate that KLRG1 is expressed on immune cells, mainly NK cells, CD8+T lymphocytes, CD4+T lymphocytes, and other T cell subsets
(NK) cells, as well as distinct subsets of T-cells, such as CD8+T-cells, CD4+T-cells, and regulatory T-cells (Tregs) [2,3,4,5]. The extracellular domain of KLRG1 on immune cells can be assessed via immunofluorescence staining and flow cytometry using KLRG1-specific antibodies, enabling...
Beyersdorf NB, Ding X, Karp K, Hanke T. Expression of inhibitory "killer cell lectin-like receptor G1" identifies unique subpopulations of effector and memory CD8T cells.Eur J Immunol. 2001; 31(12):3443-3452. Henson SM, Akbar AN. KLRG1--more than a marker for T cell senescence.Age ...
CD8+ T cells play a crucial role in the clearance of intracellular pathogens through the generation of cytotoxic effector cells that eliminate infected cells and long-lived memory cells that provide enhanced protection against reinfection. We have previously shown that the inhibitor of E protein ...