NAC resulted in an increase only of CD20(+) B cells, whereas NAPC increased the infiltration of CD20(+) B cells, CD4(+) T cells, CD4(+)CD127(+) T cells, CD8(+) T cells, CD8(+)CD127(+) and CD8(+)KLRG1(+) T cells. Synergistic increase in B and T cells promotes favorable ...
KLRG1表达与活化T淋巴细胞增殖以及活化NK细胞效应功能的减少相关。3KLRG1在先天和适应性免疫系统中的白细胞调节中发挥作用,被视为一种细胞衰老或分化标记物。例如,KLRG1可用于定义急性感染4和癌症5中的CD8 T细胞亚群,以区分短寿效应(KLRG1highCD127low)以及记忆前体(KLRG1lowCD127high)CD8 T细胞。6...
clusters tended to decrease (Fig.1d, e). This trend in cell ratios reflects the possibility that CD127-expressing T cells and KLRG1-expressing CD8+T cells are the main immune cell types mediating anti-tumor immunity after the addition of PD-1 blockade to neoadjuvant chemotherapy. We compared ...
KLRG1 is not expressed on mast cells in mice or humans [2,13,30]. Recent advances indicate that KLRG1 is expressed on immune cells, mainly NK cells, CD8+T lymphocytes, CD4+T lymphocytes, and other T cell subsets
KLRG1 is also expressed on subsets of CD8+ and CD4+ cells, including CD4+ and CD8+ effector/memory cells, potent regulatory CD4+ T cells. KLRG1 may be involved in regulating NK cell homeostasis. KLRG1 was found to recognize cadherins and thus inhibit immune responses by regulating the ...
(NK) cells, as well as distinct subsets of T-cells, such as CD8+T-cells, CD4+T-cells, and regulatory T-cells (Tregs) [2,3,4,5]. The extracellular domain of KLRG1 on immune cells can be assessed via immunofluorescence staining and flow cytometry using KLRG1-specific antibodies, enabling...
During acute infection, antigen-specific CD8 T cells expand and differentiate CD8 memory precursor effector cells (MPECs), which express KLRG1highCD127low, and short-lived effector cells (SLECs), which express KLRG1lowCD127high.7CD127, the receptor for interleukin 7, can dictate a cell’s lon...
CD8+ T cells play a crucial role in the clearance of intracellular pathogens through the generation of cytotoxic effector cells that eliminate infected cells and long-lived memory cells that provide enhanced protection against reinfection. We have previously shown that the inhibitor of E protein ...
Indeed, antigen-specific CD8+ T cells targeting persistent viruses (e.g., human immunodeficiency virus and Epstein-Barr virus) have been shown to have low CD127 and high KLRG1 expressions, while CD8+ T cells targeting resolved viral antigens (e.g., FLU) typically display high CD127 and ...