Furthermore, KLRG1− CD127+ cells isolated within a week after infection exhibit a gene expression profile that is related to that of memory cells isolated after clearance of the infection (Best et al., 2013). Expression of CD127 is vital for MPCs, as this is the receptor for IL-7, ...
than KLRG1−CD127+CD8+T-cells. Therefore, the modulation of CD8+T-cell differentiation in FL by PI3K inhibitors may promote a more effective antitumor immune response and thus improve the clinical prognosis of lymphoma patients [121]. KLRG1 may also be a marker for monitoring antitumor response...
the ratios of CD4+T cells, CD4+CD127+T cells, CD8+T cells, CD8+CD127+T cells, and CD8+KLRG1+T cells did not change significantly in post-NAC versus pre-NAC, reflecting the limited immune activation
than KLRG1−CD127+CD8+T-cells. Therefore, the modulation of CD8+T-cell differentiation in FL by PI3K inhibitors may promote a more effective antitumor immune response and thus improve the clinical prognosis of lymphoma patients [121]. KLRG1 may also be a marker for monitoring antitumor response...
NAC resulted in an increase only of CD20(+) B cells, whereas NAPC increased the infiltration of CD20(+) B cells, CD4(+) T cells, CD4(+)CD127(+) T cells, CD8(+) T cells, CD8(+)CD127(+) and CD8(+)KLRG1(+) T cells. Synergistic increase in B and T cells promotes favorable ...
Analysis of CD127 and KLRG1 expression on hepatitis C virus-specific CD8+ T cells reveals the existence of different memory T-cell subsets in the periphera... Thimme R.Analysis of CD127 and KLRG1 expression on hepatitis C virus-specific CD8+ T cells reveals the existence of different memory...
In contrast, a low expression of inhibitory receptors by the remaining HCV-specific CD8+ T cells occurred in concert with a CD127hi phenotype, an early T cell differentiation stage and presence of viral sequence variations within the corresponding epitopes. In sum, these results suggest that T ...
KLRG1表达与活化T淋巴细胞增殖以及活化NK细胞效应功能的减少相关。3KLRG1在先天和适应性免疫系统中的白细胞调节中发挥作用,被视为一种细胞衰老或分化标记物。例如,KLRG1可用于定义急性感染4和癌症5中的CD8 T细胞亚群,以区分短寿效应(KLRG1highCD127low)以及记忆前体(KLRG1lowCD127high)CD8 T细胞。6...
However, the dramatic reduction in KLRG1hi cells caused by loss of Id2 remained in the absence of Bim, such that Id2/Bim double-deficient cells form an exclusively KLRG1lo CD127hi memory precursor population. Thus we describe a role for Id2 in both the survival and differentiation of ...
In contrast, a low expression of inhibitory receptors by the remaining HCV-specific CD8+ T cells occurred in concert with a CD127hi phenotype, an early T cell differentiation stage and presence of viral sequence variations within the corresponding epitopes...