包涵体肌炎的发病机制被随着时间的推移,T细胞的慢性抗原刺激会导致原始或早期效应记忆T细胞(TEM1和TEM2细胞)转化为高度分化的克隆细胞毒性CD8+ T细胞(TEM3、TEM4和终末分化(TEMRA)细胞),经CD8+CD28、CD8+CD244+、CD8+CD57+或CD8+KLRG1+)和CD4+ T细胞(CD4+CD28)存在于包涵体肌炎(IBM)肌肉和血液中。这些晚期T细胞...
The capacity of CD4+ T cells to proliferate and secrete IL-2 cytokine was inversely associated with the level of KLRG1 expression. Importantly, blocking KLRG1 signaling resulted in a significant improvement in CD4+ T cell proliferation and IL-2 production in HCV-infected, HBV vaccine nonresponders...
KLRG1 has also been detected in a few bacterial infections, such asMycobacterium tuberculosis(Mtb) andHelicobacter pylori(H. pylori) [90,98]. During Mtb infection, KLRG1 is overexpressed on lung CD4+T-cells, and these KLRG1+CD4+T-cells secrete significantly greater amounts of IFN-γ, IL-2,...
人KLRG1在大量NK细胞、淋巴因子激活杀伤(LAK)细胞和贴壁LAK(A-LAK)细胞亚群,以及在CD8+和CD4+T淋巴细胞亚群上表达,但不在肥大细胞上表达。1BD开发了一种靶向人KLRG1的新型重组单克隆抗体(rMab),它可改善分离并有可能帮助区分表达KLRG1的新型免疫细胞亚群。
(NK) cells, as well as distinct subsets of T-cells, such as CD8+T-cells, CD4+T-cells, and regulatory T-cells (Tregs) [2,3,4,5]. The extracellular domain of KLRG1 on immune cells can be assessed via immunofluorescence staining and flow cytometry using KLRG1-specific antibodies, enabling...
The capacity of CD4(+) T cells to proliferate and secrete IL-2 cytokine was inversely associated with the level of KLRG1 expression. Importantly, blocking KLRG1 signaling resulted in a significant improvement in CD4(+) T cell proliferation and IL-2 production in HCV-infected, HBV vaccine non...
adeegbe do et al. bet bromodomain inhibition cooperates with pd-1 blockade to facilitate antitumor response in kras-mutant non-small cell lung cancer. cancer immunol res. 2018 oct;6(10):1234-1245. vicente r et al. nonclassical cd4+cd49b+ regulatory t...
KLRG1 is alsoexpressed on subsets of CD8 and CD4 cells, including CD4 and CD8 effector/memory cells,potent regulatory CD4 T cells. KLRG1 may be involved in regulating NK cell homeostasis.KLRG1 was found to recognize cadherins and thus inhibit immune responses by regulating theeffector function ...
Targeting KLRG1 with specific antibodies significantly restores the capacity of NK cells to kill HIV-infected cells, reactivates latent HIV present in CD4+ T cells co-expressing KLRG1, and reduces the intact HIV genomes in samples from ART-treated individuals. Our data support the potential use of...
摘要 目的探讨胃癌患者外周血、癌及癌旁组织淋巴细胞中CD4+T、CD8+T、NK及NKT细胞上杀伤细胞凝集素样受体G1(Killer cell lectin-like recepto...展开更多 ObjectiveTo investigate the difference of killer cell lectin-like receptor G1(KLRG1)and T cell immunoglobulin and ITIM domains(TIGIT)expression levels...