中文名称:SARS-CoV-2 滴鼻感染 K18-hACE2转基因小鼠模型 英文名称:SARS-CoV-2-infected K18-hACE2 transgenic mice model for COVID-19 类型:SARS-CoV-2 感染动物模型 分级:NA 用途:为研究SARS-CoV-2入脑途径、神经毒性与相关机制以及抑制神经损伤药物的研发和转化提供了工具。
模型信息中文名称:SARS-CoV-2 滴鼻感染 K18-hACE2转基因小鼠模型英文名称:SARS-CoV-2-infected K18-hACE2 transgenic mice model for COVID-19类型:SARS-CoV-2 感染动物模型分级:NA用途:为研究SARS-CoV-2入脑途径、神经毒性与相关机制以及抑制神经损伤药物的研发和转化提供了工具。 价格说明 价格:商品在爱采购...
Fig. 3Intranasal vaccination with CVXGA1 protects K18-hACE2 transgenic mice against SARS-CoV-2 infection. Mice received DMEM intranasally, CVXGA1 immunization via intranasal (106 PFU) route, UV-inactivated SARS-CoV-2 (UV-SARS2) administered via intramuscular route with alum adjuvant followed by...
Due to the shortage of COVID-19 patient tissues, we used brain cortexes from transgenic K18-hACE2 mice, but the ubiquitinomes of mice infected with SARS-CoV-2 are somewhat different from those of humans, which reduces the reliability of our results. In addition, it has been shown that ...
Intranasal (IN) administration of BreC-CoV-2 in K18-hACE2 mice induced a strong systemic and localized immune response in the respiratory tissues which provided protection against the Washington strain of SARS-CoV-2. Protection provided after IN administration of BReC-CoV-2 was associated with ...
Here, we show that transgenic mice expressing the human SARS-CoV-2 receptor (angiotensin-converting enzyme 2 [hACE2]) under a cytokeratin 18 promoter (K18) are susceptible to SARS-CoV-2 and that infection resulted in a dose-dependent lethal disease course. After inoculation with either 10 ...
K18 hACE2 transgenic mice are, therefore, highly susceptible to SARS-CoV-2 infection and represent a suitable animal model for the study of viral pathogenesis, and for identification and characterization of vaccines (prophylactic) and antivirals (therapeutics) for SARS-CoV-2 infection and associated...
To address this uncertainty, the K18-hACE2 mouse model has emerged as a primary tool. These mice are transgenic and express the human hACE2 gene under the control of the cytokeratin-18 (k18) promoter [28]. This model has been frequently employed in initial investigations concerning the patho...
Here, using K18-human ACE2 (hACE2) mice, we confirmed the validity of RG-rescued SARS-CoV-2 viruses to reproduce the infection profile, clinical disease, and pathogenesis already established in mice infected with natural SARS-CoV-2 isolates, often patient derived. RG-rescued SARS-CoV-2-...
We investigated the potential use of CBD, which has so far proven to have a positive effect on different diseases, in the SARS-CoV-2 infection. To test this, invivo studies were carried out using K18-hACE2 transgenic mice. To reveal the potential therapeutic effect of the ...