This chapter focuses on the application of transgenic mice to address various problems of skeletal biology such as the effects of protein structure and gene regulation on bone structure or bone cell differentiation. Transgenic mice provide an excellent setting for studying complex regulatory systems that...
APP/PS1 transgenic mouse, a widely used animal model for AD, can be used in lots of aspects for AD related study, such as neuronal apoptosis, inflammation, cholinergic abnormal, neurogenesis disorder and synaptic plasticity. Despite all this, APP/PS1 transgenic mice model is not a perfect ...
for the purpose of visualizing the interactions between red fluorescence labeled human glioma cells and host brain cells.This may offer references for further studying the roles of tumor microenvironment during glioma tissue remodeling.Methods Transgenic female C57BL/6 mice expressing enhanced green ...
Rapid advances in the field of molecular biology have led to the application of sophisticated techniques (e.g., recombinant DNA technology, chimeric models, transgenic mice, and stem cell manipulation). 相关知识点: 试题来源: 解析 (1)分子生物学领域的快速进步带来了尖端技术(如DNA重组技术、嵌合模...
Stem cells (SCs) have been used therapeutically for decades, yet their applications are limited by factors such as the risk of immune rejection and potential tumorigenicity. Extracellular vesicles (EVs), a key paracrine component of stem cell potency, ov
Overload of intracellular Ca(2+) has been implicated in the pathogenesis of neuronal disorders, such as Alzheimer's disease. Various mechanisms produce abn... S Kim,H Rhim - 《Molecules & Cells》 被引量: 53发表: 2011年 Early neurovascular dysfunction in a transgenic rat model of Alzheimer'...
Due to the adhesion between neutrophils and chondrocytes, these nanoparticles not only have the ability to neutralize pro-inflammatory cytokines and suppress inflammatory responses in arthritic mice but also possess the capability to aggregate and penetrate the cartilage matrix in the distal part of the...
[21], using a transgenic mouse model which spontaneously develops asthma, confirmed some of the results. In this study, Ym1 and Ym2 were upregulated both at the protein and mRNA level, comparing control versus asthmatic mice. After dexamethasone treatment, Ym1 mRNA levels decreased whereas Y...
Characterization of the transgenic mice that broadly expressMetRSL274G To enable the in vivo labeling of mammalian proteome via broad expression of mMetRSL274G, we crossed floxed STOP-EGFP taggedMetRSL274Gmice (i.e., fx mice) with CMV-Cre mice (Fig.1a). Fx mice were generated using conve...
On the other hand, it has been reported that transgenic mice expressing human AβPP (APP/Ld) that in turn carry a knockin mutation in mitochondrial DNA (mt-DNA) polymerase γ (PolgA D257A), show severe mitochondrial bioenergetic defects and an increase of individual´s mortality after their...