to the selection of human lens clouding due to a variety of causes has become an important means of studying the pathogenesis of cataract.Therefore,the research on the application of transgenic mice to the molecular pathogenesis of cataracts will be the main topic of this review of the ...
Transgenic (Tg) mice containing intact BAC molecules are likely to show physiologically-relevant gene expression patterns and copy number-dependent expression levels. BACs are usually used for overexpression studies and rescue experiments of knockout mice; however, these large DNA molecules tend to ...
involves various unique phenotypic alterations in cells [32,33]. Despite the proportion of senescent cells in the vascular system of the elderly is generally low, several mechanisms of cellular senescence have been demonstrated that may damage vascular function and promote the progression...
Laboratory mice (Mus musculus) have become the major model species for inner ear research. The major uses of mice include gene discovery, characterization, and confirmation. Every application of mice is founded on assumptions about what mice represent and how the information gained may be generalized...
Wang S, Nong X, Yang G (2019) Selenium-rich diet induces myocardial structural and functional abnormalities by activating caspase-9 and caspase-3 in Gpx-1P198L-overexpression transgenic mice. Med Sci Monit 25:61–70 Article CAS PubMed PubMed Central Google Scholar Wang R, Ha KY, Dhandapani...
Anti-beta s-ribozyme reduces beta s mRNA levels in transgenic mice: potential application to the gene therapy of sickle cell anemia. Blood Cells Mol. Diseases 25 (2), 110 - 119.R. Alami, J.G. Gilman, Y.Q. Feng, A. Marmorato, I. Rochlin, S.M. Suzuka, M.E. Fabry, R.L. ...
Characterization of the transgenic mice that broadly express MetRS L274G To enable the in vivo labeling of mammalian proteome via broad expression of mMetRSL274G, we crossed floxed STOP-EGFP tagged MetRSL274G mice (i.e., fx mice) with CMV-Cre mice (Fig. 1a). Fx mice were generated ...
Stem cells (SCs) have been used therapeutically for decades, yet their applications are limited by factors such as the risk of immune rejection and potential tumorigenicity. Extracellular vesicles (EVs), a key paracrine component of stem cell potency, ov
[21], using a transgenic mouse model which spontaneously develops asthma, confirmed some of the results. In this study, Ym1 and Ym2 were upregulated both at the protein and mRNA level, comparing control versus asthmatic mice. After dexamethasone treatment, Ym1 mRNA levels decreased whereas Y...
Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging[J]. Magn Reson Med, 2003, 50(2): 293−302. DOI: 10.1002/mrm.10529. [28] Sigurdsson EM, Wadghiri YZ, Mosconi L, et al. A non-toxic ligand for voxel-based MRI analysis of plaques in AD ...