英文名称:SARS-CoV-2-infected K18-hACE2 transgenic mice model for COVID-19 类型:SARS-CoV-2 感染动物模型 分级:NA 用途:为研究SARS-CoV-2入脑途径、神经毒性与相关机制以及抑制神经损伤药物的研发和转化提供了工具。 研制单位:中国医学科学院医学实验动物研究所 ...
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参考资料: Jian Zheng et al.COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice. Nature, 2020, doi:10.1038/s41586-020-2943-z.
模型信息中文名称:SARS-CoV-2 滴鼻感染 K18-hACE2转基因小鼠模型英文名称:SARS-CoV-2-infected K18-hACE2 transgenic mice model for COVID-19类型:SARS-CoV-2 感染动物模型分级:NA用途:为研究SARS-CoV-2入脑途径、神经毒性与相关机制以及抑制神经损伤药物的研发和转化提供了工具。 价格说明 价格:商品在爱采购...
相关研究结果近期发表在Nature期刊上,论文标题为“COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice”。 图片来自Pixabay/CC0 Public Domain。 由其他启动子驱动的hACE2转基因小鼠也已被开发出来,在SARS-CoV-2感染后观察到不同的结果。值得注意的是,K18-hACE2小鼠也支持鼻鼻窦上皮内...
Tracking inflammation resolution signatures in lungs after SARS-CoV-2 omicron BA.1 infection of K18-hACE2 mice doi:10.1371/journal.pone.0302344SARS-CoV-2REGULATORY T cellsCOVID-19ADULT respiratory distress syndromeINNATE lymphoid cellsThe severe acute respiratory syndrom...
We show that BA.5 and XBB isolates were significantly more pathogenic in K18-hACE2 mice than a BA.1 isolate, showing increased neurotropic potential, resulting in fulminant brain infection and mortality, similar to that seen for original ancestral isolates. BA.5 also...
Rothan, H.A.; Kumari, P.; Stone, S.; Natekar, J.P.; Arora, K.; Auroni, T.T.; Kumar, M. SARS-CoV-2 Infects Primary Neurons from Human ACE2 Expressing Mice and Upregulates Genes Involved in the Inflammatory and Necroptotic Pathways. Pathogens2022, 11, 257. ...
(BCG) vaccine on the immune response to SARS-CoV-2 infection, including the neurodegenerative diseases it may contribute to. To explore this, an experimental study was carried out in BCG-stimulated and non-stimulated k18-hACE2 mice challenged with SARS-CoV-2. Viral loads in tissues determined...
We explored the ubiquitinome and proteome in the cortex of K18-hACE2 mice infected or not infected with SARS-CoV-2 and studied the differences between the SARS-CoV-2 infection group and the control group to examine the relationship between the neurological consequences of COVID-19 and ubiquitin...