T淋巴母細胞(Jurkat) AntizymeTet-On SystemT cell activationCytokineJurkat T cellAntizyme (AZ) directly binds ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis, and inactivates and degrades ODC by the 26S proteasome without ubiquitination. The production of full-length functional...
Jurkat cells naturally express functional NFAT proteins, a family of transcription factors involved in T cell activation, differentiation, and self-tolerance [1, 2]. NFAT activation is controlled by calcium influx upon T cell receptor (TCR) stimulation [1, 2]. Several therapeutic approaches have ...
These cells were derived from the Jurkat-Lucia™ NFAT cell line which is deficient for the cluster of differentiation 28 (CD28). The Jurkat-Lucia™ NFAT-CD28 cell line was generated by the stable expression of CD28 to establish the full T cell activation. They feature an NFAT-inducible Lu...
Thus, capsaicin and its numerous analogs may have potential use as immunomodulatory drugs and should be further investigated in models of inflammation and T-cell activation.Access through your organization Check access to the full text by signing in through your organization. Access through your ...
"Weiss A, et al. The role of T3 surface molecules in the activation of human T cells: a two-stimulus requirement for IL-2 production reflects events occurring at a pre-translational level. J. Immunol. 133: 123-128, 1984. PubMed: 6327821 ...
The nuclear factor of activator T cells (NFAT) family of transcription factors plays an important role in immune response. T cell activation through the T cell synapse results in calcium influx. Increased intracellular calcium levels activate the calcium-sensitive phosphatase, calcineurin, which rapidly...
人T淋巴细胞白血病细胞Jurkat_TCH-C225_MX028A6-20250304.pdf 该细胞是Jurkat-FHCRC细胞株(Jurkat细胞株的衍生)的一个克隆。Jurkat细胞株来源于一个14岁男孩的外周血;经佛波酯和外源凝集素或抗T3单克隆抗体中的一种诱导后可产生大量IL-2(IL-2的产生需两种类型的诱导剂);表达T细胞受体、CD3。 细胞名称:人T淋巴...
人T淋巴细胞白血病细胞Jurkat,货号:TCH-C225-1X10^6 该细胞是Jurkat-FHCRC细胞株(Jurkat细胞株的衍生)的一个克隆。Jurkat细胞株来源于一个14岁男孩的外周血;经佛波酯和外源凝集素或抗T3单克隆抗体中的一种诱导后可产生大量IL-2(IL-2的产生需两种类型的诱导剂);表达T细胞受体、CD3。 细胞名称:人T淋巴细胞白血病...
Interleukin- (IL-) 2 is the major growth factor for T-cell activation and proliferation. IL-2 has multiple functions in the regulation of immunological processes. Although most studies focus on T-cell immunomodulation, T-cell activation by IL-2 is the foundation of priming the feedback loop....
细胞名称:Jurkat-Cas9细胞 人T淋巴细胞白血病细胞Cas9稳定表达细胞系 细胞简称:Jurkat-Cas9细胞 产品货号:TCH-C225-M01 修饰基因:Cas9 修饰类型:过表达稳转 转导方法:慢病毒转染 抗性基因:Hygro 细胞鉴定:Q-PCR检测合格 种属来源:人 组织来源:外周血 疾病特征:急性T淋巴细胞白血病 细胞形态:淋巴母细...