原代T细胞或PBMC及Jurkat T 细胞激活测试(T Cell Activation Assay) T细胞或PBMC活化测定试验确定受试品对T细胞或PBMC在细胞活化过程中的调节作用。 东大生物的方法可以评估测试品在由CD3 / CD28抗体诱导下的T细胞或PBMC 活化中的作用,测试方式包括用细胞因子的ELISA或流式细胞仪(FCM)的测定。 案例一:原代T细胞激活后...
et al. Essential role of the adaptor protein Nck1 in Jurkat T cell activation and function. Clin Exp Immunol 167, 99-107 (2012).Yiemwattana I, Ngoenkam J, Paensuwan P, Kriangkrai R, Chuenjitkuntaworn B and Pongcharoen S. Essential role of the adaptor protein Nck1 in Jurkat T cell...
The nuclear factor of activator T cells (NFAT) family of transcription factors plays an important role in immune response. T cell activation through the T cell synapse results in calcium influx. Increased intracellular calcium levels activate the calcium-sensitive phosphatase, calcineurin, which rapidly...
The interaction with STAT6 requires the Tyr127 residue and Lck-binding domain of Tip, which are indispensable for interleukin (IL)-2-independent T-cell transformation by HVS. It was also demonstrated that Tip induces nuclear translocation of STAT6, as well as activation of STAT6-dependent ...
cell(P<0.05). Conclusion 1.CyPApromoteproliferation,activation andchemotaxisofJurkat eell; 2.CD147 play roles inthe CyPA-inducedbiological functionof Jurkatcell. KEYWORDSJurkat cell;CyclophilinA;CD 1 47;Cellproliferation; activation;chemotaxis IV ...
Necrosis versus apoptosis as the mechanism of target cell death induced by Entamoeba histolytica. Infect. Immun. 65: 3615-3621, 1997. PubMed: 9284127 Churchill MJ, et al. The rev-responsive element negatively regulates human immunodeficiency virus type 1 env mRNA expression in primate cells. J....
Intercellular communication involves either direct cell-cell contact or release and uptake of diffusible signals, two strategies mediated by distinct and l... G Paratcha,F Ledda,CF Ibá?Ez - 《Cell》 被引量: 970发表: 2003年 Alternative p38 activation pathway mediated by T cell receptor-proximal...
(2001). Bcl-2 over-expression and activation of protein kinase C suppress the trail-induced apoptosis in Jurkat T cells. Cell. Res. 11 (2): 101-106.B.C. Guo, Y.H. Xu, Bcl-2 over-expression and activation of protein kinase C suppress the trail-induced apoptosis in Jurkat T cells,...
Cell Biology InternationalMa, S., H. Ochi, L. Cui, and W. He. 2003. FasL-induced downregulation of CD28 expression on jurkat cells in vitro is associated with activation of caspases. Cell Biol. Int. 27: 959-964.FasL-induced downregulation of CD28 expression on Jurkat cells in vitro is ...
Key words: escin sodium; leukemia Jurkat cells; apoptosis; cell proliferation; antitumor 细胞凋亡的缺失在肿瘤发生,发展过程中起重 要作用,并影响肿瘤转移及预后.肿瘤细胞逃避凋 亡的能力在其对常规治疗药物产生抗药性中发挥重 要作用.因此,选择性地诱导肿瘤细胞凋亡已成为 抗肿瘤药物研发的一个重要策略[1-3]...