(1953). Mode of action of isoniazid. Am. Rev. Tuberc. 67, 490.Albert, A. Mode of action of isoniazid. Nature 177, 525-526 (1956).Barclay WR, Ebert RH, Koch-Weser D. Mode of action of isoniazid. Part 1. Am Rev Tuberc 1953;67:490-496....
The known mode of action of isoniazid (INH) is to inhibit bacterial cell wall synthesis following activation by the bacterial catalase﹑eroxidase enzyme KatG in Mycobacterium tuberculosis (Mtb). This simplistic model fails to explain following (1) how INH penetrates waxy granulomas with very low ...
et al. Metabolic studies on the possible mode of action of isoniazid tumorigenicity. J Cancer Res Clin Oncol 99, 153–166 (1981). https://doi.org/10.1007/BF00412451 Download citation Received08 May 1980 Accepted03 October 1980 Issue DateFebruary 1981 DOIhttps://doi.org/10.1007/BF00412451 Key...
Metabolism of isoniazid by Mycobacterium tuberculosis BCG with reference to current theories of the mode of action 来自 Semantic Scholar 喜欢 0 阅读量: 17 作者: J Youatt 摘要: KRÜGER-THIEMER (Amer. Rev. Tuberculosis, 1958, v. 77, 364) has suggested that organs susceptible to isoniazid do ...
The effectiveness of isoniazid in combating TB and its mode of action being is the "yin" to the "yang" in relation to its side effects. This review focuses on one particular side effect induced by isoniazid, namely systemic lupus erythematosus (SLE). The condition of drug-induced lupus is ...
Furthermore, the most active compounds 178b-d showed activity to a similar extent against various MDR-Mtb strains, thus revealing a distinct mode of action. Sign in to download hi-res image Fig. 38. Fused 1,2,4-triazoles anti-TB potential. Various triazolopyrimidines 180 (Fig. 38...
The authors conclude that such close structural congeners of metabolites of INH may serve as significant leads in antitubercular drug discovery and in the exploration of the mode of action of INH.doi:10.1080/10559610390450705Michael J Hearn
Isoniazid (INH), the most prescribed drug to treat TB, inhibits an NADH-dependent enoyl-acyl carrier protein reductase (InhA) that provides precursors of mycolic acids, which are components of the mycobacterial cell wall. InhA is the major target of the mode of action of isoniazid. INH is ...
MetabolitesGenetic and Biochemical Studies of Antibiotic Activity and ResistanceMechanism and Evolution of Antibiotic ResistanceMechanisms and Structural Biology of Antibiotic ActionNovel Antimicrobial AgentsPharmacokinetics and Pharmacodynamics of DrugsPlant-Derived AntibioticsThe Global Need for Effective Antibiotics...
The number of effective first-line antibiotics for the treatment of Mycobacterium tuberculosis infection is strongly limited to a few drugs. Due to emerging resistance against those drugs, second- and third-line antibiotics have been established in thera