Mechanism of action Isoniazid is a prodrug and must be activated by bacterial catalase. Specficially, activation is associated with reduction of the mycobacterial ferric KatG catalase-peroxidase by hydrazine and reaction with oxygen to form an oxyferrous enzyme complex. Once activated, isoniazid inhibit...
The risk of hepatitis must be weighed against the risk of tuberculosis in positive tuberculin reactors over the age of 35. However, the use of isoniazid is recommended for those with the additional risk factors listed above (1 to 6) and on an individual basis in situations where there is li...
The risk of hepatitis must be weighed against the risk of tuberculosis in positive tuberculin reactors over the age of 35. However, the use of isoniazid is recommended for those with the additional risk factors listed above (1 to 6) and on an individual basis in situations where there is li...
Isoniazid is the frontline drug employed in the treatment of tuberculosis. Recent research has probed the mechanism of action of isoniazid (INH), a key drug in the chemotherapy of tuberculosis and also the anti-mycobacterial potential of derivatives of isoniazid has been evaluated. We have made ...
The mechanism of action of isoniazid is not known, but it is thought to work through its effects on lipids (fats) and DNA within the tuberculosis bacterium. It is very selective for the tuberculosis bacteria and it has few if any effects on other bacteria. Common side effects of isoniazid ...
Mechanism of action study: K. Johnsson et al., J. Am. Chem. Soc. 117, 5009 (1995). Toxicity data: E. H. Jenney, C. C. Pfeiffer, J. Pharmacol. Exp. Ther. 122, 110 (1958). Evaluation of carcinogenic risk: IARC Monographs 4, 159 (1974). Comprehensive description: G. A. Brewer...
Mechanism of Action Isoniazid inhibits the synthesis of mycoloic acids, an essential component of the bacterial cell wall. At therapeutic levels isoniazid is bactericidal against actively growing intracellular and extracellular Mycobacterium tuberculosis organisms. Resistance Resistance to isoniazid occurs because...
Metabolism of isoniazid by Mycobacterium tuberculosis BCG with reference to current theories of the mode of action 来自 Semantic Scholar 喜欢 0 阅读量: 17 作者: J Youatt 摘要: KRÜGER-THIEMER (Amer. Rev. Tuberculosis, 1958, v. 77, 364) has suggested that organs susceptible to isoniazid do ...
Understanding of the molecular changes which lead to isoniazid resistance [11], have been important not only in understanding resistance but also in understanding the mechanism of action of this mainstay of anti-tubercular therapy and of identifying new possible treatments [6,7,12]. Whilst INH ...
Mechanism of actionIsoniazid is active against susceptible bacteria only when they are undergoing cell division. Susceptible bacteria may continue to undergo one or two divisions before multiplication is arrested. Isoniazid can inhibit the synthesis of mycolic acids, which are essential components of myco...