Another mechanism for isoniazid resistance, in M. smegmatis, occurs by defects in NADH dehydrogenase (Ndh) of the respiratory chain. Genetic data indicated that ndh mutations confer resistance by lowering the rate of NADH oxidation and increasing the intracellular NADH/NAD+ ratio. An increased ...
However, INH resistant strains which do not have mutations in any of these genes are reported, suggesting that these strains may adopt some other mechanism to become resistant to INH. In the present study we characterized Rv2170, a putative acetyltransferase in M. tuberculosis, to elucidate its ...
Mechanism of action Isoniazid is a prodrug and must be activated by bacterial catalase. Specficially, activation is associated with reduction of the mycobacterial ferric KatG catalase-peroxidase by hydrazine and reaction with oxygen to form an oxyferrous enzyme complex. Once activated, isoniazid inhibit...
The above treatment guidelines apply only when the disease is caused by organisms that are susceptible to the standard antituberculous agents. Because of the impact of resistance to isoniazid and rifampin on the response to therapy, it isessentialthat physicians initiating therapy for tuberculosis be ...
Secondary resistance originates when the drug is used independently without simultaneous use of another effective antituberculosis drug, such as isoniazid and rifampin. The mechanism of resistance to this drug is not known. Synonyms of ethambutol are diambutol, chlorbutinol, tibistal, tubet...
Mechanism of Action Isoniazid inhibits the synthesis of mycolic acids, an essential component of the bacterial cell wall. At therapeutic levels isoniazid is bacteriocidal against actively growing intracellular and extracellularMycobacterium tuberculosisorganisms. ...
Mechanism of Action Isoniazid inhibits the synthesis of mycoloic acids, an essential component of the bacterial cell wall. At therapeutic levels isoniazid is bactericidal against actively growing intracellular and extracellular Mycobacterium tuberculosis organisms. Resistance Resistance to isoniazid occurs because...
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP. J Am Chem Soc. 2007 Aug 8;129(31):9582-3. PMID: 17636923. Oliveira JS, Vasconcelos IB, Moreira IS, et al. Enoyl reductases as targets for...
This review summarises all facts concerning a front-line antituberculotic drug isoniazide - metabolism, mechanism of activity and resistance. The antimycobacterial pharmacophore moiety of isoniazide has been introduced in a number of various types of molecules (about 510 derivatives have been found) ...
The Molecular Mechanism and Fast Detection of Isoniazid Resistance of Mycobacterium Tuberculosis 结核分支杆菌异烟肼耐药的分子机制及其快速鉴定 属类:中国大陆-www.ilib.cn- The influence on Isoniazid and Rifampicin drug susceptibility of the different bacterium quantity in Mycobacterium tuberculosis 结核分枝杆菌...