ISONIAZID ( iso nicotinylhydrazide), which has proved remarkably successful in the treatment of human tuberculosis, has an affinity for the ions of heavy metals. This affinity is only slightly less than those of the common amino-acids 1 . It has been claimed that the action of isoniazid (I...
et al. Metabolic studies on the possible mode of action of isoniazid tumorigenicity. J Cancer Res Clin Oncol 99, 153–166 (1981). https://doi.org/10.1007/BF00412451 Download citation Received08 May 1980 Accepted03 October 1980 Issue DateFebruary 1981 DOIhttps://doi.org/10.1007/BF00412451 Key...
The known mode of action of isoniazid (INH) is to inhibit bacterial cell wall synthesis following activation by the bacterial catalase﹑eroxidase enzyme KatG in Mycobacterium tuberculosis (Mtb). This simplistic model fails to explain following (1) how INH penetrates waxy granulomas with very low ...
Bekierkunst A, Bricker A (1967) Studies on the mode of action of isoniazid on mycobacteria. Arch Biochem Biophys 122: 385–392 PubMed CAS Google Scholar Bergogne-Berezin E, Modai J (1975) Comparison of isoniazid inactivation in African Negroes and in Europeans. Rev Fr Mal Resp 3: 397...
Daily administration of isoniazid for one year to persons infected with Mycobacterium tuberculosis is effective in considerably reducing the risk of disease. From a practical viewpoint, this approach to prevention is less than ideal beca... DE Snider,GJ Caras,JP Koplan - 《Jama the Journal of th...
Answer to: Compare and contrast the three modes of photosynthesis. List the advantages and disadvantages of each mode. By signing up, you'll get...
2022, Nucleic Acids Research Deciphering Isoniazid Drug Resistance Mechanisms on Dimeric Mycobacterium tuberculosis KatG via Post-molecular Dynamics Analyses Including Combined Dynamic Residue Network Metrics 2022, ACS Omega View all citing articles on Scopus ...
The pharmacophoric search for protein ligands with three-dimensional structures similar to TIA resulted in several protein ligands with Tanimoto score equal to or greater tha 0.5, but only the ligand isoniazid (ISZ) was bound to a protein from plant origin, which ...
BMC Research Notes 2012, 5:526 http://www.biomedcentral.com/1756-0500/5/526 SHORT REPORT Open Access Role of Serine140 in the mode of action of Mycobacterium tuberculosis β-ketoacyl-ACP Reductase (MabA) Leonardo A Rosado1,2,4, Rafael Andrade Caceres2,3, Walter Filgueira de Azevedo Jr3...
isoniazidlysismetabolismNo Abstract available for this article.doi:10.1007/BF00629331Tirunarayanan, M. OVischer, W. ASpringer-VerlagNaturwissenschaftenMaher, J.R., Speyer, J.F., Levine, M. (1957) Mode of action of isoniazid. Am. Rev. Tuberc. 75: pp. 517-518Maher , J. R., J. F. ...