Isoniazid, Mechanism of Action, Biological Activity, Resistance and Biotransformationdoi:10.21608/JAMPR.2023.202321.1052Badawy, Ebtisam T.Ragab, Amany E.Kabbash, AmalEl-seoud, Kamilia A. AboJournal of Advanced Medical & Pharmaceutical Research
Mechanism of action Isoniazid is a prodrug and must be activated by bacterial catalase. Specficially, activation is associated with reduction of the mycobacterial ferric KatG catalase-peroxidase by hydrazine and reaction with oxygen to form an oxyferrous enzyme complex. Once activated, isoniazid inhibit...
Isoniazid Sucralfate may decrease the excretion rate of Isoniazid which could result in a higher serum level. Isosorbide Isosorbide may increase the excretion rate of Sucralfate which could result in a lower serum level and potentially a reduction in efficacy. Isosorbide mononitrate Sucralfate may decrea...
Our previous study showed that the anticonvulsant Q808 might be effective against seizures induced by maximal electroshock, pentylenetetrazole (PTZ), isoniazid (ISO), thiosemicarbazide (THIO), and 3-mercaptopropionic acid (3-MP). In the present study, we explored the possible mechanism of action of...
Pyrazinamide is available as a pure tablet in strengths of 150, 400, or 500mg under multiple trade names and also as a part of fixed drug combinations with rifampicin and isoniazid. Its mechanism of action of is still disputed, but pyrazinamide has a sterilizing action and treatment-...
New lipophilic isoniazid derivatives and their 1,3,4-oxadiazole analogues: Synthesis, antimycobacterial activity and investigation of their mechanism of action... Vosatka,Rudolf,Kratkj,... - 《European Journal of Medicinal Chemistry Chimie Therapeutique》 被引量: 1发表: 2018年 加载更多来源...
[124]. Subsequently, Yuichi Wakamoto et al. combined microfluidic culture with time-lapse microscopy to monitor the killing ofMycobacterium smegmatisby isoniazid (INH) at the single-cell level and found thatMycobacterium smegmatisproduces persisters by division in the presence of INH [11]. Based on...
Isoniazid Ampicillin may decrease the excretion rate of Isoniazid which could result in a higher serum level. Isosorbide Isosorbide may increase the excretion rate of Ampicillin which could result in a lower serum level and potentially a reduction in efficacy. Isosorbide mononitrate Ampicillin may decrea...
aspects of the search for agents that are effective against drug-sensitive and drug-resistantMycobacterium tuberculosis.Thiacetazone (TAC) is an anti-tubercular drug that was formerly used in conjunction with isoniazid, but removed from the antitubercular chemotherapeutic arsenal due to toxic side ...
Isoniazid Icosapent may decrease the excretion rate of Isoniazid which could result in a higher serum level. Isoprenaline The risk or severity of hypertension can be increased when Icosapent is combined with Isoprenaline. Isosorbide mononitrate Icosapent may decrease the excretion rate of Isosorbide mononi...