The vinylogues of phenylbutazone,30 and of pethidine (C. G. Wermuth, unpublished results) have the same type of activity as the parent drug, but the duration of action, especially for the pethidine analogue, is notably shorter than that of the initial molecule (Fig. 12.21). This is proba...
The risk of hepatitis must be weighed against the risk of tuberculosis in positive tuberculin reactors over the age of 35. However, the use of isoniazid is recommended for those with the additional risk factors listed above (1 to 6) and on an individual basis in situations where there is li...
Yellow skin or a yellowish tinge to the whites of the eyes Persistent fatigue Weakness Fever of greater than 3 days duration Abdominal tenderness or discomfort, especially in the right upper part of the abdomen OTHER RARE : Damage to nerves (peripheral neuropathy) may occur with isoniazid and ca...
The risk of hepatitis must be weighed against the risk of tuberculosis in positive tuberculin reactors over the age of 35. However, the use of isoniazid is recommended for those with the additional risk factors listed above (1 to 6) and on an individual basis in situations where there is li...
Side effectsThe incidence and severity of adverse reactions to isoniazid are related to dosage and duration of therapy. Isoniazid-induced hepatitis and peripheral neuropathy are two major untoward effects. Side effectsToxic effects are unusual on recommended doses and are more frequent in slow acetylat...
These include any of the following: unexplained anorexia, nausea, vomiting, dark urine, icterus, rash, persistent paresthesias of the hands and feet, persistent fatigue, weakness or fever of greater than 3 days duration and/or abdominal tenderness, especially right upper quadrant discomfort. If ...
The optimal duration of treatment is not definite because, apart from early trials with streptomycin,86 there is only one controlled trial in the treatment of intracranial tuberculomas or TBM. Rajeswari et al.87 tested the efficacy of a short-course chemotherapy in the treatment of brain...
Five hundred seventy eight participants were lost to follow-up during the study period and were censored, together with the 460 participants alive at the end of the study (Table 2). The median follow-up duration of the cohort was 839 days with 5491.2 person-years (PYs) in total. In ...
The duration of IPT is documented in the medical records of each patient. Since the introduction of the IPT guideline [38], there has been no published data on the current rate of implementation of IPT and the performance of the Mantoux test (a form of tuberculin skin test) in the ...
(14)C-isoniazid (INH) was used to study the relationship between drug uptake or binding by Mycobacterium tuberculosis and growth inhibition of the organism, which is dependent upon the concentration of drug and the duration of exposure. ... WH Beggs,JW Jenne,WH Hall - 《Journal of Bacteriolog...