INH is a very effective first-line anti-TB drug. However, it is known that patients who take INH to cure TB suffered side effects. Thus, many investigations were carried out in the 1970s with a focus on the toxicity of INH42. INH is known to induce liver cancer in rats43, but it ...
Shows preference for long-chain fatty acyl thioester substrates (>C16), and can also use 2-trans-enoyl-CoAs as alternative substrates (PubMed:7599116). The mycobacterial FAS-II system utilizes the products of the FAS-I system as primers to extend fatty acyl chain lengths up to C56, ...
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There should be continuous sharing of performance data between program managers and the health facilities to motivate quality improvement in IPT implementation. HIV data review meetings should routinely include IPT indicators for PLHIV. Demand creation activities for IPT should take a three-pronged approac...
Studies have shown that individu- als who were educated on the need to take IPT by their doctors/nurses are more likely to adhere to therapy than those who were not counselled [15, 16]. It is also impor- tant for health workers to adhere to the IPT guidelines, this will help in the...
Isoniazid is a first-line drug in antitubercular therapy. Isoniazid is one of the most commonly used drugs that can cause liver injury or acute liver failure, leading to death or emergency liver transplantation. Therapeutic approaches for the prevention of isoniazid-induced liver injury are yet to...