cholesterolEnv clusteringgp41 cytoplasmic tailsHIV‐1protein–lipid interactionsHIVentry requires the redistribution of envelope glycoproteins (Env) into a cluster and the presence of cholesterol (chol) in the viral membrane. However, the molecular mechanisms underlying the specific role of chol in ...
The membrane insertion ability of Aβ is critically controlled by the ratio of cholesterol to phospholipids. In a low concentration of cholesterol Aβ prefers to stay in membrane surface region mainly in a β-sheet structure. In contrast, as the ratio of cholesterol to phospholipids rises above ...
Cholesterol is a critical cellular component for T-lymphocyte cytotoxicity. Heiniger,H.,J.,... - 《Proceedings of the National Academy of Sciences》 被引量: 62发表: 1978年 Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal ...
The LM-LLO used in this study is attenuated, that is, the coding region for the C-terminal part of the LLO (cytolytic domain that binds cholesterol in the membranes) protein has been deleted, and mutations have been introduced into the prfA gene (expressed by the pGG34 vector), which ...
Lowering Cholesterol Naturally Learn how to lower your bad LDL cholesterol and improve your heart health with these 12 diet and lifestyle tips. Elaine K. HowleyandGretel SchuellerNov. 21, 2024 Foods to Stock for the Holidays Keep visitors nourished with these healthy breakfast, lunch and snack ...
Here, we characterize cholesterol metabolism in primary human EVTs and vCTBs and attribute a functional role to cholesterol transporters in the regulation of progesterone secretion in EVTs. Furthermore, we describe differential expression of hydroxy-delta-5-steroid dehydrogenase 3 beta- and steroid ...
ER Membrane of other organelle ABC (ATP-binding casette) transporter ATPase domain Phospholipid molecules The ER is close to all other organelles in the cell (mitochondria, lysosome, plasma membrane, etc) Could ABC transporter pump lipids from the ER to other membranes? Transport of cholesterol ...
This was attributed to reduced enzymatic accessibility toward the carbamate linker, which may hamper the gemcitabine release. A lower propensity of incorporation into the plasma cell membrane, which was revealed by molecular simulations, may also play a role in lower activity of cholesterol derivative....
A. Beyond DPPH: use of fluorescence-enabled inhibited autoxidation to predict oxidative cell death rescue. Cell Chem. Biol. 26, 1594–1607 (2019). Article CAS PubMed Google Scholar Zhang, X., Barraza, K. M. & Beauchamp, J. L. Cholesterol provides nonsacrificial protection of membrane ...
In all cases, HDL retroendocytosis occurred and HDL resecretion mediated [(3)H]cholesterol efflux, although to a lesser extent. Second, cell lines carrying somatic mutations in intracellular cholesterol transport were used: CHO 2-2 and CHO 3-6 cells accumulated LDL-derived lipid in the lysosome...