The distribution of cholesterol between the two leaves of the plasma membrane in mammalian cells presents a conundrum; given cholesterol's known affinity for sphingomyelin, which resides predominantly in the exoplasmic leaf, why is it that experiment finds a majority of the cholesterol in the ...
Since cholesterol in artificial and biological membranes seems to reduce permeability we have tested its relevance in the mechanism of posthypophyseal hormones action.Reported experiments seem to give evidence that hormones and their mediator displace the steroid from the membrane without modifying its ...
In addition, membrane models with 33% cholesterol have been simulated to understand the influence of cholesterol. To quantitatively access the structure and dynamics of membranes, deuterium order parameters (SCD), mass density profiles, ... I Bera,JB Klauda - 《Journal of Physical Chemistry B》 ...
Therefore, graphene needs to be close to cell or tissue surfaces8 in order to maximize its utility in bioapplications. This then raises a fundamental question: how graphene affects the plasma membrane and related cellular functions. Prior studies have documented that graphene flakes (GFs) are ...
a sterol, C27H46O, abundant in animal fats, brain and nerve tissue, meat, and eggs, that functions in the body as a membrane constituent and as a precursor of steroid hormones and bile acids: high blood levels are associated with arteriosclerosis and gallstones. ...
Different lipophilic ligands that bind to the orthosteric site of class A GPCRs are suggested to access the protein from the membrane milieu (reviewed in ref. 6). Interestingly, in recent crystal structures of rhodopsin37,38, a molecule of a commonly used detergent (that is, n-octyl β-D-...
The collective ordering process requires specific molecular-scale features that explain why different sterols have very different membrane ordering properties: the three-fold symmetry in the Chol-Chol organization arises from the cholesterol off-plane methyl groups allowing the identification of raft-...
Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients. Alzheimer's disease (AD) is characterized by the presence of senile plaques, neurofibrillary tangles, and neuronal cell loss associated with membrane chole... D Lütjohann,A Papassotiropoulos,I Bjö...
Correlations of elevated levels of hexacosanoate in erythrocyte membranes with risk factors for atherosclerosis We analyzed erythrocyte membrane C26:0 from 504 volunteers by high-performance liquid chromatography. The associations between the elevated levels of eryth... Y Antoku,K Tsukamoto,Y Miyoshi,...
Determination of the depth of BODIPY probes in model membranes by parallax analysis of fluorescence quenching The location of a series of lipophilic and lipid-attached BODIPY (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) membrane probes was analyzed by the quenching... Robert,D.,Kaiser,......