The distribution of cholesterol between the two leaves of the plasma membrane in mammalian cells presents a conundrum; given cholesterol's known affinity for sphingomyelin, which resides predominantly in the exoplasmic leaf, why is it that experiment finds a majority of the cholesterol in the ...
source of most of the cholesterol in milk. About 15% of the cholesterol is esterified as these compounds are nonpolar, they are found in the hydrophobic core of the fat globule. Cholesterol, relatively hydrophylic because of the free hydroxyl group, is found in the membrane enveloping the ...
a sterol, C27H46O, abundant in animal fats, brain and nerve tissue, meat, and eggs, that functions in the body as a membrane constituent and as a precursor of steroid hormones and bile acids: high blood levels are associated with arteriosclerosis and gallstones. ...
Different lipophilic ligands that bind to the orthosteric site of class A GPCRs are suggested to access the protein from the membrane milieu (reviewed in ref. 6). Interestingly, in recent crystal structures of rhodopsin37,38, a molecule of a commonly used detergent (that is, n-octyl β-D-...
Amyloid beta (Aβ) fibrillation kinetics and its impact on membrane polarity Arun Ajaikumar Nozomi Morishita Watanabe Hiroshi Umakoshi Journal of Bioenergetics and Biomembranes(2025) Cortical lipid metabolic pathway alteration of early Alzheimer’s disease and candidate drugs screen ...
Interestingly, this type of local organization of NBD-cholesterol at low concentrations is also observed in sphingomyelin-containing membranes. These results could be significant in membranes that have very low cholesterol content, such as the endoplasmic reticulum and the inner mitochondrial membrane, ...
et al. Smoothened stimulation by membrane sterols drives Hedgehog pathway activity. Nature 571, 284–288 (2019). Article CAS PubMed PubMed Central Google Scholar Anderson, J. T. & Droogmans, L. In Fine-Tuning of RNA Functions by Modification and Editing (ed. Henri Grosjean) 121–139 (...
Myoblasts undergo major changes in their plasma membrane during the initial steps of skeletal muscle differentiation, including major alterations in the distribution of cholesterol. Cholesterol is involved in crucial membrane functions, such as fluidity,
It co-localizes with dehydroergosterol, a marker of cholesterol, in HeLa cells and is trafficked from the plasma membrane to the endocytic recycling compartment in BHK cells. 2 它与胆固醇标记物脱氢麦角甾醇在HeLa细胞中共定位，并从BHK细胞质膜运输到的内吞循环室。2 BODIPY-cholesterol ...
Therefore, graphene needs to be close to cell or tissue surfaces8 in order to maximize its utility in bioapplications. This then raises a fundamental question: how graphene affects the plasma membrane and related cellular functions. Prior studies have documented that graphene flakes (GFs) are ...