2010. Membrane cholesterol in the function and organization of G-protein coupled receptors. Subcell. Biochem. 51:439-466.Paila YD, Chattopadhyay A. Membrane cholesterol in the function and organization of G-protein coupled receptors. Subcell Biochem 2010;51:439-66....
Cholesterol is a major constituent of eukaryotic membranes and plays a crucial role in membrane organization, dynamics, function and sorting (Yeagle, 1985, Liscum and Underwood, 1995, Schroeder et al., 1996, Fielding and Fielding, 1997, Liscum and Munn, 1999, Simons and Ikonen, 2000). The ...
Graphene possesses extraordinary properties that promise great potential in biomedicine. However, fully leveraging these properties requires close contact with the cell surface, raising the concern of unexpected biological consequences. Computational mod
Work from our laboratory has previously demonstrated the requirement of membrane cholesterol in the function of the serotonin 1A receptor, a member of the G-protein coupled receptor (GPCR) superfamily. In order to monitor the effect of cellular organization on the function of human serotonin 1A rec...
In addition, membrane cholesterol significantly modulates the stability, ligand-binding properties and function of several GPCRs (reviewed in refs 3, 4, 5, 6). Specifically, the presence of cholesterol in cell membranes can either enhance7,8,9,10,11 (that is, positively modulate) or decrease...
We have used Nε-dansyl-L-lysine as a fluorescent membrane probe, to study cells taken from tissues concerned with immune function. There is a striking similarity between the staining selectivity of this compound and that reported by others for merocyanine 540. Both compounds stain leukemic, human...
Regulation and function of cholesterol asymmetry in synaptic plasma membranes 来自 ResearchGate 喜欢 0 阅读量: 14 作者:U Igbavboa,GP Eckert,WE Mueller,WG Wood 摘要: Frankfurt (Main), Univ., Diss., 2000. Mikrofiche-Ausg.会议名称: 4th ISN Special Conference on Membrane Domains in CNS ...
In addition, the membrane-bound transcription activator sterol regulatory element-binding protein (SREBP) is trapped in the ER by SREBP cleavage activating protein (SCAP), a third protein with a sterol-sensing domain. This limits, the expression of the genes for both HMG-CoA reductase and the ...
Significant differences were found among breeds in the av. cholesterol content of their semen: Friesian, 230.89 mg%; Piedmont, 188.50; Charolais, 334.50. Significant differences were also found between the cholesterol contents of the semen and of the seminal plasma, the contents in the seminal plas...
It is also known that when these micro-domains grow in excess number, they can create abnormalities in membrane functioning and can cause various diseases such as Farber disease or breast cancer23,30–35. In particular, the number of Cer/Chol lliaqteuiidn-othrdeecreeldl m(Le0m) dboramnae...