Cholesterol decreases the fluidity of bPC bilayers, but disrupts the highly ordered gel phase of bSM, leading to a more fluid membrane. When mixed with bPC/bSM (1:1) or bPC/bSM (2:1), cholesterol induces the formation of l o phase domains. The fraction of the membrane in the l o ...
Cell cycle analyses performed in the presence of two inhibitors of cholesterol esterification, directly inhibiting ACAT (Sandoz 58-035) or the transport of cholesterol substrate from plasma membrane to endoplasmic reticulum (progesterone), indicate that each inhibitor suppressed the serum-induced DNA ...
Cholesterol makes up about 40 percent of the outer layer of themembrane, they found, and only about 3 percent of the inner layer. In response to a specific cell stimulus, the amount in the inner layer more than doubles, and the level in the outer layer drops by the same amount. They ...
Receptor-mediated endocytosis: insights from the lipoprotein receptor system The low density lipoprotein (LDL) receptor system coordinates the metabolism of cholesterol, an essential component of the plasma membrane of all mammalian... BJL Goldstein - 《Proceedings of the National Academy of Sciences of...
What is the role of the cell membrane?Cell membrane:The cell is composed of various components that provide it with functional and structural characteristics. All the organelles are contained inside the cell, suspended in the cytoplasm and outlined by a double-layered structure known as the cell ...
Role for cholesterol and caveolin‐rich membrane microdomains in controlling the activity Na+/H+ exchange 1 independently of mitogenic stimulationThe Na/Hexchanger 1 NHE-1 is a ubiquitous membrane transporter mainly involved in pH and cell volume regulation. NHE-1 activation by His carried out ...
Extracellular vesicles (EVs) are nanosized membrane-enclosed compartments that serve as messengers in cell-to-cell communication, both in normal physiology and in pathological conditions. EVs can transfer functional proteins and genetic information to alter the phenotype and function of recipient cells, ...
To further study the role of buoyant cholesterol in T cell activation, we used cholesterol oxidase (COase). COase converts cholesterol into cholestenone. Because cholestenone does not possess a 3β-hydroxyl group, it does not interact with sphingomyelin (SM) and thus perturbs raft integrity....
Bovine rotavirus (BRV) is a non-enveloped dsRNA virus that cause neonatal calf diarrhea. Lipid rafts are cholesterol-enrich membrane mircodomains that play a vital role in many cellular processes. In this study, the effect of cellular cholesterol depleti
1. Short-term incubation of the everted intestinal sacs of rats in media containing cholesterol oleate or cholesterol plus oleic acid resulted in rapid hydrolysis, but no synthesis, of the sterol ester. 2. On separation of the brush border from the rest of the mucosal cell, almost all of ...