Membrane ProteinsMembranes, ArtificialSodium-Potassium-Exchanging ATPaseModels, BiologicalThe molecular basis for the essential role of cholesterol in mammalian (and other cholesterol-requiring) cells has long been the object of intense interest. Cholesterol has been found to modulate the function of ...
membrane cholesterol, implications in receptor functioncholesterol structure, membrane, GPCRs as target for novel drug candidatesstructure and orientation of cholesterol, nonrandom distribution in domainsspecialized domains, membrane cholesterol in host–pathogen interactions...
Cholesterol is a major constituent of eukaryotic membranes and plays a crucial role in membrane organization, dynamics, function and sorting (Yeagle, 1985, Liscum and Underwood, 1995, Schroeder et al., 1996, Fielding and Fielding, 1997, Liscum and Munn, 1999, Simons and Ikonen, 2000). The ...
& Yahi, N. Lipid rafts: structure, function and role in HIV, Alzheimer's and prion diseases. Expert reviews in molecular medicine 4, 1–22, doi: 10.1017/S1462399402005392 (2002). 24. Simons, K. & Sampaio, J. L. Membrane Organization and Lipid Rafts. Csh Perspect Biol 3, doi: ARTN...
Therefore, graphene needs to be close to cell or tissue surfaces8 in order to maximize its utility in bioapplications. This then raises a fundamental question: how graphene affects the plasma membrane and related cellular functions. Prior studies have documented that graphene flakes (GFs) are ...
Cholesterol in membrane models / Cholesterol in membrane models editor, Leonard Finegold CRC Press, c1993 L Finegold - CRC Press, 被引量: 201发表: 0年 Cholesterol Is Not Crucial for the Existence of Microdomains in Kidney Brush-border Membrane Models key role in the organization of the cell...
Effects of heme oxygenase-1 expression on sterol homeostasis in rat astroglia. Central oxidation of cholesterol to oxysterols has been implicated in neuroembryogenesis, synaptic plasticity, and membrane repair. In the current study, we ... J Vaya,S Wei,S Khatib,... - 《Free Radic Biol Med》...
Cholesterol-enhanced pore formation is one evolutionary means cholesterol-free bacterial cells utilize to specifically target cholesterol-rich eukaryotic cells, thus escaping the toxicity these membrane-lytic pores might have brought onto themselves. Her
In addition, membrane cholesterol significantly modulates the stability, ligand-binding properties and function of several GPCRs (reviewed in refs 3–6). Specifically, the presence of cholesterol in cell membranes can either enhance7–11 (that is, positively modulate) or decrease12–15 (that is, ...
50% in Fu5AH rat hepatoma cells to essentially no fast pool in rabbit smooth muscle cells. These observations led us to propose a model for the mechanism and regulation of cholesterol efflux based on the interaction of the amphipathic helixes of apolipoproteins with membrane domains of cholesterol...