It has been found that cholesterol is placed in such a position that it is not readily exposed to the solvent: the hydrophobic steroid ring is oriented parallel to the membrane phospholipids, the hydroxyl group is in close vicinity to the phospholipid ester carbonyl groups and the isooctyl side...
Moreover, the Lo phase is commonly associated with cholesterol-enriched lipid rafts, which are thought to serve as platforms for signaling proteins in the plasma membrane. Cholesterol's location in lipid bilayers has been studied extensively, and it has been shown – at least in some bilayers ...
Determination of the depth of BODIPY probes in model membranes by parallax analysis of fluorescence quenching The location of a series of lipophilic and lipid-attached BODIPY (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) membrane probes was analyzed by the quenching... Robert,D.,Kaiser,......
Cholesterol In subject area: Neuroscience Cholesterol is a steroidal lipid that is present in all animal tissues and plays important roles in membrane structure, lipid metabolism, and the production of bile acids, vitamin D, and steroid hormones. It helps regulate the fluidity of membranes and is...
The composition of the plasma membrane of malignant cells is thought to influence the cellular uptake of cisplatin and to take part in developing resistance to this widespread anti-cancer drug. In this work we study the permeation of cisplatin through th
Detection of isoform 4 of the plasma membrane calcium pump in human tissues by using isoform-specific monoclonal antibodies The epitope location and specificity of monoclonal antibodies JA9, 5F10 and JA3, raised against the human plasma membrane Ca2+ pump (hPMCA), were analysed ... AJ Caride...
Ferroptosis, a form of regulated cell death that is driven by iron-dependent phospholipid peroxidation, has been implicated in multiple diseases, including cancer1–3, degenerative disorders4 and organ ischaemia–reperfusion injury (IRI)5,6. Here, using
cell types, in association with membrane cholesterol, a role in the organization of plasma membrane topology has also recently been assigned to this family... D Mizrak,M Brittan,MR Alison - 《Journal of Pathology》 被引量: 1170发表: 2008年 CD133: molecule of the moment. cell types, in ...
Now, for the first time, chemists at the University of Illinois at Chicago have used a path-breakingoptical imagingtechnique to pinpointcholesterol's location and movement within the membrane. They made the surprising finding that, in addition to its many other biological roles, cholesterol is a...
Plasma membrane cholesterol depletion resulted in significant changes in both NMDAR and AMPAR eEPSCs (Fig. 1). NMDAR eEPSCs showed a marked reduction of amplitudes as well as a shortening of deactivation times (Fig. 1A–D). The average amplitude of NMDAR eEPSCs decreased 16-fold, from 3250...