cholesterol, fluorescence correlation spectroscopy (FCS), plasma membrane, membrane biophysics, membrane lipid, membrane structure, Bodipy-cholesterol, diffusion, hindered diffusion, membrane asymmetry, model membranesCholesterol constitutes ∼30–40% of the mammalian plasma membrane, a larger fraction than ...
Ch-CnandCh-H.bComputationally optimized structure ofCh-C1at the level of B3LYP/6-31 G* in the gas phase.cSchematic illustration of one possible means to form a toroidal channel of ~1.6 nm in diameter byCh-C1, a process that is primarily assisted by cholesterol molecules (Chin blue)...
Furthermore, cholesterol reduces the fluidity of cell membranes with its rigid structure and stabilizes membranes under different conditions. Alterations in membrane fluidity further influence membrane transport processes, including Na+/K+-ATPase. Although around 70% of plasma cholesterol is esterified, ...
The distribution of cholesterol within the cell membrane is highly heterogeneous and dynamic22, with trafficking between surface and intracellular membranes helping to maintain overall cholesterol homeostasis. Intriguingly, it has been empirically demonstrated that the planar tetracyclic ring structure of ...
Chemical–Physical Changes in Cell Membrane Microdomains of Breast Cancer Cells After Omega-3 PUFA Incorporation 3 PUFA can interfere with breast cancer growth. It is suggested that these fatty acids might change the structure of cell membrane, especially of lipid raf... PA Corsetto,A Cremona,G...
Structure, energetics, and dynamics of lipid–protein interactions: A molecular dynamics study of the gramicidin A channel in a DMPC bilayer The microscopic details of lipid–protein interactions are examined using molecular dynamics simulations of the gramicidin A channel embedded in a fully hy... ...
The structure of the tetracyclic ring of cholesterol contributes to the decreased fluidity of the cell membrane as the molecule is in a trans conformation making all but the side chain of cholesterol rigid and planar. In this structural role, cholesterol reduces the permeability of the plasma ...
The researchers suspected that proteins called Asters might be responsible for carrying HDL cholesterol from the cell membrane to the interior of the cell. Asters are tethered to a structure inside the cell called the endoplasmic reticulum, a network of membranes inside the cell. The team first is...
Cholesterol is an important component to maintain the stable structure of lipid rafts on cellular membrane.For some enveloped viruses,the infection of host cell depends on the participation of cholesterol.In this paper,pretreatment of chicken embryo kidney cells(CEKs) with methyl-β-cyclodextrin(Mβ...
The crystal structure of the A2AR40 was embedded in the former membrane and the system was solvated, neutralized, adjusted to an ionic strength of 150 mM Na+Cl− and equilibrated following standard protocols (see Methods). First, we simulated a set of 4 × 1 μs replicas to study ...