aCholesterol is found in cell membranes and is used to synthesize vitamin D, bile salts and steroid hormones. 胆固醇在细胞膜被找到和用于综合维生素D、胆汁盐和甾类激素。[translate]
Numerous studies suggest that total cholesterol content of erythrocyte membranes (CEM) might play a critical role in atherosclerotic plaque progression and instability. However, the exact role of CEM in atherosclerosis remains obscure. Our study was designed to investigate the association between CEM and...
324 CHOLESTEROL CONTENT OF ERYTHROCYTE MEMBRANES IS ASSOCIATED WITH LIPID CORE SIZE IN ANIMAL MODEL OF ATHEROSCLEROSISdoi:10.1016/s1567-5688(11)70325-7D. TziakasA. KapelouzouG. ChalikiasD. StakosS. ApostolakisA. AgapakiA. KostakisH. Boudoulas...
Among the different lipid classes, cholesterol possesses particular properties: It is an essential structural component of cell membranes and a precursor of steroid hormones and bile acids. Cells gain cholesterol either by uptake from extracellular acceptors, such as lipoproteins, or by endogenous de ...
G. Intracellular distribution of the steroidal glycoalkaloid α-tomatine in Lycopersicon esculentum fruit. Phytochemistry 15, 475–477 (1976). Article CAS Google Scholar Keukens, E. A. J. et al. Glycoalkaloids selectively permeabilize cholesterol containing biomembranes. Biochim. Biophys. Acta ...
Age-related macular degeneration (AMD) is the leading cause of blindness among the elderly. Dry AMD has unclear etiology and no treatment. Lipid-rich drusen are the hallmark of dry AMD. An AMD mouse model and insights into drusenogenesis are keys to bett
A lower propensity of incorporation into the plasma cell membrane, which was revealed by molecular simulations, may also play a role in lower activity of cholesterol derivative. Résumé Il a été montré précédemment que le couplage chimique de la gemcitabine (Gem) (un anticancéreux majeur) ...
The intracellular transport of cholesterol is subject to tight regulation. The structure of the lysosomal integral membrane protein type 2 (LIMP-2, also known as SCARB2) reveals a large cavity that traverses the molecule and resembles the cavity in SR-B1
et al. ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signaling in Niemann-Pick type C. Nat. Cell Biol. 21, 1206–1218 (2019). CAS PubMed PubMed Central Google Scholar Rizzuto, R. et al. Close contacts with the endoplasmic reticulum as determinants of...
Figure 1. The structure of α-toxin and the four stages of pore assembly. A, crystal structures of monomeric lukF and of the α-toxin pore heptamer. Left, lukF is a component of staphylococcal leukocidin that is homologous to α-toxin. This crystal structure represents the monomer prior ...