Using primary human trophoblasts isolated from first trimester placental tissues, we show that cellular cholesterol homeostasis is differentially regulated in EVTs compared with villous cytotrophoblasts. Utilizing RNA-sequencing, gene set-enrichment analysis, and functional validation, we provide evidence ...
Lowering Cholesterol Naturally Learn how to lower your bad LDL cholesterol and improve your heart health with these 12 diet and lifestyle tips. Elaine K. HowleyandGretel SchuellerNov. 21, 2024 Foods to Stock for the Holidays Keep visitors nourished with these healthy breakfast, lunch and snack ...
7-Dehydrocholesterol dictates ferroptosis sensitivity. Nature, https://doi.org/10.1038/s41586-023-06983-9 (2024). Tzelepis, K. et al. A CRISPR dropout screen identifies genetic vulnerabilities and therapeutic targets in acute myeloid leukemia. Cell Rep. 17, 1193–1205 (2016). Article CAS Pub...
The peroxisome-ER cross-talk is vital for many lipid-related metabolic pathways, including the biosynthesis of ether-phospholipids, production of polyunsaturated fatty acids, cholesterol, bile acids and isoprenoids (Reviewed in [14]). For these products to be biosynthesized efficiently the ER and pe...
progressive familial intrahepatic cholestasis type 1 SCHAD, short chain L-3-hydroxyacyl-CoA Bile acids, which are synthesized from cholesterol in the liver and secreted into the small intestine, play an important role in efficient digestion and absorption of dietary fats and fat-soluble vitamins (1...
CD14+CD16+ monocytes were counted using a five-type automated hematology analyzer; mononuclear cells were assessed using fluorescence-activated cell sorting; and an automatic biochemical analyzer was used to measure the levels of triglyceride, cholesterol, high- and low-density lipoprotein cholesterols,...
To confirm that PRDX6 inhibition leads to disruption of delivery of host cell cytosol to the FV, we preloaded RBCs with pH- dependent LysoSensor Blue/Yellow that emits blue fluores- cence at neutral pH, as found in the cytosol, and yello...
The intracellular transport of cholesterol is subject to tight regulation. The structure of the lysosomal integral membrane protein type 2 (LIMP-2, also known as SCARB2) reveals a large cavity that traverses the molecule and resembles the cavity in SR-B1
In patients with complete biliary obstruction, a substantial portion of fecal sterols was found to be of nondietary origin (Stanley et al., 1959), and in bile-diverted patients, the intestinal mucosa was found to secrete 250–400 mg of cholesterol per day (Cheng and Stanley, 1959). A ...
The CYP51 proteins are found in soluble form in prokaryotes, whereas they are membrane-bound in eukaryotes67. Cholesterol in mammals, ergosterol in fungus, and phytosterols in plants are the end products of sterol biosynthesis and are crucial structural elements of eukaryotic membranes68. Selectivity...