HIVentry requires the redistribution of envelope glycoproteins (Env) into a cluster and the presence of cholesterol (chol) in the viral membrane. However, the molecular mechanisms underlying the specific role of chol in infectivity and the driving force behind Env clustering remain unknown. Here, ...
The membrane insertion ability of Aβ is critically controlled by the ratio of cholesterol to phospholipids. In a low concentration of cholesterol Aβ prefers to stay in membrane surface region mainly in a β-sheet structure. In contrast, as the ratio of cholesterol to phospholipids rises above ...
faecium M74® (reduction in serum cholesterol levels), E. mundtii ST4SA (production of bacteriocins), E. faecium LCW 44 and E. durans 6HL (production of antimicrobial compounds against Gram-positive and Gram-negative bacteria) [25]. Regarding feed regulation, the EFSA authorized certain ...
7-Dehydrocholesterol dictates ferroptosis sensitivity. Nature, https://doi.org/10.1038/s41586-023-06983-9 (2024). Tzelepis, K. et al. A CRISPR dropout screen identifies genetic vulnerabilities and therapeutic targets in acute myeloid leukemia. Cell Rep. 17, 1193–1205 (2016). Article CAS Pub...
The LM-LLO used in this study is attenuated, that is, the coding region for the C-terminal part of the LLO (cytolytic domain that binds cholesterol in the membranes) protein has been deleted, and mutations have been introduced into the prfA gene (expressed by the pGG34 vector), which ...
Cytotoxic cholesterol is generated by the hydrolysis of cytoplasmic cholesteryl ester and transported to the plasma membrane. Cytotoxic cholesterol is generated by the hydrolysis of cytoplasmic cholesteryl ester and transported to the plasma membrane. Atherosclerosis 1999; 146:309-19... G Kellner-Weibel,...
Conclusions We conclude from these studies that membrane-based cholesterol and in particular that localized to lipid rafts, is an indispensable biomolecule for PRV infection, and that cholesterol-based control of the infection process takes place during entry and immediately post-entry into the cell.Ba...
(UniProt: AAEL008004) which is a cholesterol responding acetoacetyl-CoA synthase. Six others are involved in metabolism and among them the sterol regulatory element binding protein 1 involved in regulating the transcription of the LDL receptor gene which is a key regulatory element in the promoter...
The bacterial sphingomyelinase from Bacillus cereus also inhibited the entry of HIV-1, which indicated that ceramide derived from the degradation of SM may reduce the susceptibility of cells to membrane fusion. Ceramide was previously shown to translocate cholesterol from lipid rafts to the liquid-...
The intracellular transport of cholesterol is subject to tight regulation. The structure of the lysosomal integral membrane protein type 2 (LIMP-2, also known as SCARB2) reveals a large cavity that traverses the molecule and resembles the cavity in SR-B1