In this Perspective, Zhang discusses the latest advances in understanding of iron function, regulation and metabolism, as well as the implications for ferroptosis in health and disease.doi:10.1038/s41556-024-01361-7Zhang Donna D.Nature Publishing Group UKNature cell biology...
Ironing-Out the Details: New Strategies for Combining Ferroptosis Inhibitors with Immunotherapy in MelanomaMichael F. EmmonsKeiran S.M. Smalley
Ferroptosis constitutes a promising therapeutic strategy against cancer by efficiently targeting the highly tumorigenic and treatment-resistant cancer stem cells (CSCs). We previously showed that the lysosomal iron-targeting drug Salinomycin (Sal) was able to eliminate CSCs by trigg...