et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149, 1060–1072 (2012). This study introduces the term ferroptosis to describe a novel form of non-apoptotic cell death and identifies the small molecule ferrostatin 1 as the first specific inhibitor of ferroptosis. ...
Ferroptosis is defined as an iron-dependent form of regulated cell death that occurs through the lethal accumulation of reactive oxygen species (ROS) when the glutathione-dependent lipid peroxidation repair systems are compromised, contributing to cell death (Stockwell et al., 2017). ...
Ferroptosis is an iron-dependent new programmed cell death, which is quite different from other classical programmed cell death, including apoptosis, necroptosis, senescence and autophagy both in morphology and biological properties [9,10]. Hitherto a series studies have revealed that ferroptosis is inv...
^1. Dixon, S.J., et al., Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell, 2012. 149(5): p. 1060-72. ^Yang, W.S. and B.R. Stockwell, Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer...
Ferroptosis: an iron-dependent form of nonapoptotic cell death Cell, 149 (2012), pp. 1060-1072 View PDFView articleView in ScopusGoogle Scholar Doncel et al., 2017 J.P. Doncel, P.de la C. Ojeda, M. OropesaÁvila, M.V. Paz, I. De Lavera, M.D. La Mata, M.Á. Córdoba, R...
ferroptosislabile ironcalcium overloadmitochondrial calcium uniportercell deathoncosisapoptosisFerroptosis is a recently identified iron-dependent form of nonapoptotic cell death characterized by reactive oxygen species(ROS) generation and lipid peroxidation.Here,we report a novel iron-dependent form of ferropt...
Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149:1060–72. Article CAS PubMed PubMed Central Google Scholar Fearnhead HO, Vandenabeele P, Vanden TB. How do we fit ferroptosis in the family of regulated cell death? Cell Death Differ. 2017;24:1991–8. ...
and mitochondrial biogenesis is an iron-dependent process. During osteoclast differentiation, key genes in heme-dependent and TF-dependent iron intake pathways are highly upregulated, and the expression of SLC39A14 (an NTBI iron transporter) and Scara-5 and Tim-2 (ferritin transporters) are either...
Clear cell renal cell carcinoma (ccRCC) is still highly aggressive and lethal even with various therapeutic approaches. As the kidney is an iron metabolism-related organ, exploring and assessing the clinical value of ferroptosis, an iron-dependent regula
Ferroptosis, an iron-dependent non-apoptotic form of cell death, mediates its effects in part by promoting the accumulation of reactive oxygen species. The inhibition of ferroptosis decreases clinical symptoms in experimental models of ischemia/reperfusion-induced renal failure and heart injury. This ...