Iron overload disor- ders: natural history, pathogenesis, diagnosis, and therapy. Crit Rev Clin Lab Sci. 1983;19:205-66.McLaren GD, Muir WA, Kellermeyer RW. Iron overload disorders: natural history, pathogenesis, diagnosis, and therapy. Crit Rev Clin Lab Sci 1983; 19:205-266...
Noun1.iron overload- pathology in which iron accumulates in the tissues; characterized by bronzed skin and enlarged liver and diabetes mellitus and abnormalities of the pancreas and the joints bronzed diabetes,hemochromatosis,iron-storage disease ...
Hereditary hemochromatosis (HH) is a disease of iron overload leading to the accumulation of iron in specific organs including the liver, heart, pancreas and gonads. From:The International Journal of Biochemistry & Cell Biology,2001 About this page ...
In hemochromatosis, this regulatory mechanism is impaired and an excess amount of iron is absorbed from the intestines regardless of the iron stores already in the body, resulting in iron overload. Because the body does not have a mechanism to rid the excess iron, this imbalance between gains ...
A C282Y homozygote is considered at considerable risk for developing iron overload disease. However, not every C282Y homozygote develops iron overload. A C282Y/H63D compound heterozygote is a person who has inherited one mutated C282Y gene from one parent and a second mutated H63D gene from ...
Primary Iron Overload Primary iron overload results from inherited defects in genes involved in iron absorption, transport, or regulation.Hemochromatosis,the most common disease of primary iron overload, can be partitioned into 4 types. The most common is Classic (Type I) or HFE hemochromatosis....
Iron Overload in Human Disease Iron is both essential and toxic. The authors review how the body absorbs, uses, and loses iron and explore both common and unusual causes of iron overload and treatment of the resulting disorders. RE Fleming,P Ponka - N Engl J Med 被引量: 0发表: 2012年...
Iron overload, notably caused by hereditary hemochromatosis, is an excess storage of iron in various organs that causes tissue damage and may promote tumorigenesis. To manage that disorder, free iron depletion can be induced by iron chelators like deferoxamine that are of increasing interest also ...
1) Iron Overload and Diseases 铁过度负荷与疾病2) Iron overload 铁过负荷 1. In order to establish a simple and fast diagnosis technique for animal iron overload in clinic and laboratory,natural clinical cases were used to study. 为动物铁过负荷建立简单、快捷的临床和实验室诊断技术,利用临床...
Hereditary iron overload includes several disorders characterized by iron accumulation in tissues, organs, or even single cells or subcellular compartments. They are determined by mutations in genes directly involved in hepcidin regulation, cellular iron uptake, management and export, iron transport and ...