and hepatitis C viral infection. Chronic liver disease decreases the synthetic functions of the liver, including the production of hepcidin, a key protein in iron metabolism. Lower levels of hepcidin result in iron overload, which leads to iron deposits in the liver and higher levels of non-tra...
Long-term iron overload can have severe consequences. Liver cancer, diabetes and other endocrine disorders, cardiomyopathy and heart disease, and even Parkinson’s and Alzheimer’s disease have all been linked with excessive iron accumulation. ...
and deferasirox are used as iron chelators in the transfusion overload disorders. In disorders of intravascular hemolysis (e.g., transfusion, sepsis, sickle cell disease), free hemoglobin and hemin are released. Both hemoglobin and hemin are toxic and produce adverse clinical conditions involving va...
Centers for Disease Control and Prevention (2002). "Iron deficiency – United States, 1999–2000". MMWR. 51 (40): 897–99. PMID 12418542. Hider, Robert C.; Kong, Xiaole (2013). "Chapter 8. Iron: Effect of Overload and Deficiency". In Astrid Sigel, Helmut Sigel and Roland K.O. Si...
It can be differentiated from the so called secondary iron overloads that can be found in similar clinical-pathological charts which are caused by other primary processes [2]. The term secondary or acquired hemochromatosis has largely been abandoned in favour of defining the primary disease, for ...
Iron overload thalassemic cardiomyopathy: iron status assessment and mechanisms of mechanical and electrical disturbance due to iron toxicity. Can. J. Cardiol. 25, 213–218 (2009). Article CAS Google Scholar Zurlo, M. G. et al. Survival and causes of death in thalassaemia major. Lancet 2,...
Alcoholics who were heterozygotes for H63D mutation and had evidence of iron overload, showed an even greater risk of developing liver disease [odds ratio 2.17 (95% CI 1.42-3.32)]. Based on these findings, it appears that iron overload is an important co-factor in the development of ...
Iron homeostasis is essential for health; moreover, hepcidin-deficiency results in iron overload in both hereditary hemochromatosis and iron-loading anemia. Here, we identified iron modulators by functionally screening hepcidin agonists using a library of 640 FDA-approved drugs in human hepatic Huh7 ...
Iron chelators have been widely used to remove excess toxic iron from patients with secondary iron overload. However, small molecule-based iron chelators can cause adverse side effects such as infection, gastrointestinal bleeding, kidney failure, and liv
In addition, previous study in pregnant women has also demonstrated that iron supplementation during pregnancy is not beneficial for pregnant women who are homozygous for Hb E but a routine intervention should not cause iron overload as judged from short observation period30. This is very important...