which underscores the need to understand its long-term consequences on population health. Although iron overload is less prevalent, its extreme form—hemochromatosis—can lead to severe clinical manifestations10. Previous research on iron-regulating pathways...
A recent study has further demonstrated that non-transferrin bound iron (NTBI) may potentially increase cardiovascular risk by promoting atherosclerotic plaque formation in a mouse model for atherosclerosis and iron overload (ApoE−/− FPNwt/C326S)(Vinchi et al., 2019). A clinical study on ...
Serum ferritin, as a marker of liver iron stores, was identified as an independent predictor of NAFLD as early as 2012 [9], and hyperferritinemia was often even the first abnormality leading to medical attention in such patients [31]. The most frequent inherited form of iron overload, hered...
The primary therapeutic approach for AI is detection and treatment of the underlying inflammatory disease, which usually results in resolution of AI over time [2]. Anti-inflammatory treatment in patients with AI based on auto-inflammatory disorders was demonstrated to ameliorate anemia in addition to...
receptor inhibitors (ARIs), primarily enzalutamide, are often inconsistent and unpredictable, with only transiently beneficial effects. Advanced-stage disease is characterized by disease heterogeneity, which makes one-size-fits-all treatment generally ineffective. Moreover, drug toxicity may limit the dose...