Iron OverloadMass ScreeningPublic Health PracticeResearchHereditary hemochromatosis type 1, also known as hereditary hemochromatosis classical (HHC), is an iron overload disorder associated, in most cases, with mutations of the hemochromatosis (HFE) gene. Although suggested algorithms for diagnosing iron ...
Iron-overload cardiomyopathy is a RCM that manifests systolic or diastolic dysfunction secondary to increased deposition of iron in the heart and occurs with common genetic disorders such as primary hemochromatosis. From: Post-Genomic Cardiology, 2007 ...
Iron chelators have been widely used to remove excess toxic iron from patients with secondary iron overload. However, small molecule-based iron chelators can cause adverse side effects such as infection, gastrointestinal bleeding, kidney failure, and liver fibrosis. Here we report renal clearable na...
Of these, HFE hemochromatosis (HFE-HC) is by far the most frequent... EAF Ofliver - 《Journal of Hepatology》 被引量: 172发表: 2010年 Iron-Overload Cardiomyopathy: Pathophysiology, Diagnosis, and Treatment of survival in patients with secondary iron overload, while also being a leading ...
Inhalation as a source of iron in secondary iron overload. J Andrew,Ghio - 《Acta Haematologica》 被引量: 3发表: 2014年 Rat alveolar macrophage-derived platelet-derived growth factor is chemotactic for rat lung fibroblasts. Alveolar macrophages and their products are thought to be important ...
Iron overload also increased the serum levels of ALT and AST as the biomarkers of hepatic function and decreased the serum Alb levels. These results suggested that both kidney and liver were damaged by excessive iron. In addition, iron overload induced low I-PTH secre- tion and high level ...
ultimately excreted when the mucosal cell is shed into the intestinal lumen. The potential for iron overload via this route of absorption is extremely low due to tight regulation mediated by iron regulatory proteins intracellularly and hepcidin extracellularly[6]. The citrate moiety can also be ...
Also, we found robust increase in the fluorescent intensity in diabetic HFE KO retinal sections compared to diabetic HFE WT sections (Fig. 5A). However, this effect was not surprising as it is known that iron overload promotes Fenton’s reaction, thereby increasing oxidative stress9. Labile ...
Pig iron produced in the blast furnace is purified and converted to steel in a separate furnace, known as a basic-oxygen furnace. Jets of pure oxygen gas at high pressure are blown over and through the pig iron melt. Metal impurities are converted into oxides. Part of the dissolved carbon...
It will be of interest to perform more chronic studies and assess long term changes in cardiac remodeling induced by Lcn2 and whether cardiac iron content is increased in such animals. Indeed, iron overload is known to cause elevated oxidative stress, myocardial apoptosis, systolic and diastolic ...