It will be of interest to perform more chronic studies and assess long term changes in cardiac remodeling induced by Lcn2 and whether cardiac iron content is increased in such animals. Indeed, iron overload is known to cause elevated oxidative stress, myocardial apoptosis, systolic and diastolic ...
IRon Overload screeNing tool (IRON): development of a tool to guide screening in primary care. Iron overload is associated with significant morbidity and mortality yet is easily treated. The objective of this study was to create a tool that could be ... AGM Iii,VA Diaz,CJ Everett,... ...
Iron overload: accuracy of in-phase and out-of-phase MRI as a quick method to evaluate liver iron load in haematological malignancies and chronic liver dis... Objectives: The purpose of this prospective study was to evaluate the accuracy of inphase and out-of-phase imaging to assess hepatic...
Iron is an essential element involved in many human physiological processes [25]. Iron chelators, such as deferoxamine (DFO, also Desferal) and deferasirox (Exjade), have been used to treat iron overload diseases [26]. Epidemiological evidence suggests that excessive iron contributes to tumor init...
What is Hemochromatosis? Hemochromatosis is a hereditary condition that causes the body to accumulate an excess of iron. Iron deficiency and iron overload are both relatively common, and the difference between the two is only a few milligrams. As the body does not have an efficient method of ...
At the apical membrane of the enterocyte, Fe3+ is converted to Fe2+ by ferrireductase, also known as duodenal cytochrome B (DCYTB), followed by its uptake mediated by DMT1 (Fig. 25.12). DMT1 also transports other metal ions (e.g., Cu2+, Zn2+, and cobalt). The internalized Fe2+ ...
production of glucose-6-phosphatase (G6Pase), an enzyme that catalyzes the last step in gluconeogenesis, is known to be inhibited by both insulin and AMPK [17]. AMPK can be activated by iron overload, thus supporting the view that iron acts as a suppressor of gluconeogenesis. Furthermore,...
Aquatic ecosystems are vulnerable to excess iron load as it can cause direct or indirect effect on lotic organisms by disturbing the normal metabolism and osmoregulation. Furthermore, higher iron availability in water could also lead to endocrine disruption in fishes. However, the impact of iron ov...
Hepatocyte iron overload with cirrhosis, as seen in hereditary haemochromatosis, has an established link to the development of hepatic cancer [101] and there seems to be a link between high dietary iron intake and colorectal cancer [102]. Notably, models that investigated iron as a potential ...
Iron chelators have been widely used to remove excess toxic iron from patients with secondary iron overload. However, small molecule-based iron chelators can cause adverse side effects such as infection, gastrointestinal bleeding, kidney failure, and liv