It will be of interest to perform more chronic studies and assess long term changes in cardiac remodeling induced by Lcn2 and whether cardiac iron content is increased in such animals. Indeed, iron overload is known to cause elevated oxidative stress, myocardial apoptosis, systolic and diastolic ...
Iron-overload cardiomyopathy is a RCM that manifests systolic or diastolic dysfunction secondary to increased deposition of iron in the heart and occurs with common genetic disorders such as primary hemochromatosis. From: Post-Genomic Cardiology, 2007 ...
zebrafishObjectivesThalassemia is the most common genetically inherited blood disorder arising from a defect in hemoglobin production, resulting in ineffective erythropoiesis and severe hemolytic anemia. While transfusion therapy corrects the anemia, it gives rise to secondary iron overload. Current iron ...
Iron chelators have been widely used to remove excess toxic iron from patients with secondary iron overload. However, small molecule-based iron chelators can cause adverse side effects such as infection, gastrointestinal bleeding, kidney failure, and liver fibrosis. Here we report renal clearable na...
Iron homeostasis is essential for health; moreover, hepcidin-deficiency results in iron overload in both hereditary hemochromatosis and iron-loading anemia. Here, we identified iron modulators by functionally screening hepcidin agonists using a library o
mucosal cell is shed into the intestinal lumen. The potential for iron overload via this route of absorption is extremely low due to tight regulation mediated by iron regulatory proteins intracellularly and hepcidin extracellularly[6]. The citrate moiety can also be absorbed systemically in the ...
Iron overload also increased the serum levels of ALT and AST as the biomarkers of hepatic function and decreased the serum Alb levels. These results suggested that both kidney and liver were damaged by excessive iron. In addition, iron overload induced low I-PTH secre- tion and high level ...
Pig iron produced in the blast furnace is purified and converted to steel in a separate furnace, known as a basic-oxygen furnace. Jets of pure oxygen gas at high pressure are blown over and through the pig iron melt. Metal impurities are converted into oxides. Part of the dissolved carbon...
Inhalation as a source of iron in secondary iron overload. J Andrew,Ghio - 《Acta Haematologica》 被引量: 3发表: 2014年 Rat alveolar macrophage-derived platelet-derived growth factor is chemotactic for rat lung fibroblasts. Alveolar macrophages and their products are thought to be important ...
Iron has been shown to trigger oxidative stress by elevating reactive oxygen species (ROS) and to participate in different modes of cell death, such as ferroptosis, apoptosis and necroptosis. However, whether iron-elevated ROS is also linked to pyroptosi